Bye Cancer
It is my honor to hypothesize the end of cancer for all we know it with sufficient flush niacin... View more
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Cancer Cachexia
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Cancer Cachexia
JUST PUBLISHED! This paper shows the importance of niacin for maintaining NAD homeostasis & how it affects cancer cachexia.
Decreased liver B vitamin-related enzymes as a metabolic hallmark of cancer cachexia:
“Metabolomic analysis reveals alterations of metabolites related to NAD and one-carbon (C1) metabolism in severe cancer cachexia models”
“NAD was decreased in muscle and liver of our four cancer-bearing models (Fig. 2a; Table S2)13,26,27,28,29….alteration of NAD metabolism is present in muscle and liver of cancer-bearing and is associated with cachexia severity.
NAD-related metabolites belong to a B vitamin subgroup, niacin (NIA), also known as vitamin B322.
These results imply that hepatic B-vitamin enzymes are highly expressed in healthy conditions and exhibit an abundance-dependent decline as a group in cancer cachexia.”
https://www.nature.com/articles/s41467-023-41952-w
nature.com
Cancer cachexia is a multifactorial metabolic syndrome affecting a large fraction of patients with advanced cancer. Here the authors report a decrease in B vitamin-related liver enzymes in mouse models and gastric cancer patients with cachexia.
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Here is some more good news– the apparent no limit to cancer reducing activity of niacin:
“The benefit associated with increasing niacin intake in further reduction in cancer mortality had no apparent plateau (Supplementary Fig. 1).”
bmccancer.biomedcentral.com
Background The vitamin niacin is used as a lipid-regulating supplement, but it is unknown whether niacin has a positive influence on cancer prognosis. In this study, we examine the relationship between niacin intake and mortality among patients with cancer. Methods … Continue reading
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