Bye Cancer
It is my honor to hypothesize the end of cancer for all we know it with sufficient flush niacin... View more
Organizer:
- Organized by
-
-
Reply To: Does Glutamine feed cancer?
-
You are referring to garbage papers with simply conceptual theorization (and misconception on their part) with authors who do not understand the glutamine metabolism as trying to provide glutamine to the cancer cells so they do NOT cancer (more then too), but still NOT enough glutamine… you do NOT kill/toxify/oxidize cancer cells to kill them / cure the cancer and you … no .. that will only kill you … the cancer cells, themselves, are still our actual cells, just making ATP the only way they can favorably now (by way of lack of niacin, glutamine to provide enough energy flux) via glycolysis and so making lactate more = the actual tumor … it is still the SAME CELL … just need actual exogenously delivered glutamine with niacin to remodulate and turn it back to the mitochondria and not have the lactate buildup = cure of cancer …
These same authors who made up these stupid attempts to say glutamine being the only fuel source for cancer cells to not die/fail and you die but still have the opportunity to be readily reverted back/cured, is fueling cancer growth are reckless and just flat-out wrong. You realize this when you finally do experimentation, including in humans rather than thoughts in the head. The idiots who falsely recklessly claim these lies about glutamine, of course, then also do this as so-called rationale to starve glutamine further (and killing the cells and you further) by inhibiting then even endogenous metabolism of it with their garbage, expensive Nazi nerve agent inhibitors (to KILL the cell… thus you… slowly, painfully)…
“Our data support the hypothesis that glutamine is a likely alternative energy source during niacin deficiency”
“Since the levels of NAD in niacin deficient cells are greatly reduced, it is likely that NAD-depleted cells are incapable to sustain their energy requirements solely by glycolysis. Therefore, niacin deficient cells would require an additional carbon source. One such source available from the cell culture media is glutamine. We hypothesized that if glutamine is a crucial carbon source for NAD-depleted cells, these cells would be far more sensitive than control cells if it was removed from the media. Completely eliminating glutamine from the media lead to cell death both in control and depleted cells”
Niacin restriction upregulates NADPH oxidase and reactive oxygen species (ROS) in human keratinocytes.
https://europepmc.org/article/med/17997992…
“One concern about the administration of Gln to cancer patients is that it would be employed by rapidly proliferating cells, including malignant cells,51 with the potential enhancement of tumour growth. However, some experimental data appear to indicate that dietary supplements do not increase tumour growth,52 rather, it diminishes growth53,54 by enhancing NK cell activity through the support of host Gln stores and glutathione (GSH) production. Presently, it remains to be clarified as to whether Gln might inhibit tumour metastasis”
“we demonstrated for the first time in this study that Gln [glutamine] inhibited PAF-associated tumour metastasis, in which MAPKs perform a critical role, via the deactivation of ERK, JNK, and p38 MAPKs.”
Glutamine inhibits platelet-activating factor-mediated pulmonary tumour metastasis
https://sci-hub.ru/10.1016/j.ejca.2011.07.013…
“We further demonstrated that dietary glutamine supplementation partially increased glutamine levels and restored potent antitumor responses”
Glutamine is essential for overcoming the immunosuppressive microenvironment in malignant salivary gland tumors
https://biorxiv.org/content/10.1101/2022.04.29.490103v1…
“Taken together, our results provide a previously unidentified mechanism by which glutamine supplementation inhibits melanoma tumour growth and suggests a previously unrealized therapeutic avenue using glutamine supplementation in melanoma to cooperate with current therapies and potentially combat resistance mechanisms. Furthermore, our results provide important evidence that glutamine supplementation, rather than the nutrient-limiting approaches, is a simple dietary intervention that has the potential to block melanoma tumour growth and potentiate the effects of anti-melanoma treatments by suppressing epigenetically activated oncogenic pathways.”
Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth
https://nature.com/articles/s41467-020-17181-w…
“The overall incidence of postoperative complications was 14.9 and 36.8% in the glutamine and control groups, respectively, indicating that glutamine significantly reduced the incidence of postoperative complications [p < 0.001; risk ratio (RR) 0.41 [95% CI 0.30–0.54]]. Compared with the control group, the glutamine group had a significantly lower postoperative infection complications rate (10.5 vs. 28.9%; p < 0.001; RR 0.36 [95% CI 0.26–0.52]).”
“Moreover, glutamine supplementation alleviated the decrease in albumin (p < 0.001), total protein (p < 0.001), and prealbumin levels (p < 0.001).”
Postoperative parenteral glutamine supplementation improves the short-term outcomes in patients undergoing colorectal cancer surgery: A propensity score matching study
Tang, Gang et al in Frontiers in Nutrition (2023.03)
https://frontiersin.org/articles/10.3389/fnut.2023.1040893/full