[Dr.Kats]

So which dose ratio are you doing exactly of the GPR109A capsules to Swanson iron citrate capsules (assuming you have this Swanson iron citrate: https://www.swansonvitamins.com/p/swanson-premium-iron-citrate-25-mg-60-veg-caps)? It looks to be best at 5 GPR109A Capsules (which is 1,250 mg or 1.25 g flush niacin worth) with every 1 Swanson iron citrate capsule (25 mg “iron” on the back). I know we had it way too high at first (at even flipped, 4.5 Swanson iron citrate capsules per 1 GPR109A capsules), but we had no reference point to go off. We now know it’s way closer to and may be right around 5 GPR109A capsules (1.25 g niacin) per 1 Swanson iron citrate capsule (25 mg “iron”). Let me know which ratio you were doing…

Also, along with the Swanson Iron Citrate capsules, do you happen to have solo, separate products of flush niacin by Pure Bulk (whether in capsules or powder) and folic acid by Pure Bulk (or someone else, but make sure it is only folic acid and not methylfolate), separately? It is worth trying niacin + iron citrate in ratio of 1.25 g niacin + 25 mg “iron” (i.e., 1 Swanson iron citrate capsule) OR niacin + folic acid + iron citrate in ratio of 1.25 g niacin + 1.525 m(illi)g(rams) folic acid + 25 mg “iron” (i.e., 1 Swanson iron citrate capsule) — that is, without the acetylglutamine. Per what we are learning about iron citrate, especially some of these brand new papers, it looks like the dysregulation of glutamine/amino acids metabolism (and the lack of that little bit of folic acid) may be subordinate endogenously to namely the iron (citrate) and niacin deficiency, in that restoring simply iron citrate with niacin (ideally at ideal stoichiometric ratio together, whatever that exactly is, but it looks to be no less than an amount of 1.25 g niacin (which note is 2.5 Pure Bulk flush niacin 500-mg each capsules) per each 25 mg “iron” (i.e., 1 Swanson iron citrate capsule). I believe supplementing ANY kind of amino acids (including even acetylglutamine and especially the heat-labile free l-glutamine as we saw before) may be worthless to supplement, especially during a pellagra (which looks to be namely a niacin + iron (citrate) deficiency, potentially folic acid too, but I believe we can circumvent it), as again, it is seeming to be uncovered that all amino acids’ metabolisms, including glutamine/glutamate’s (the most important/regulating of all amino acids) are regulated by iron status, modulated in fine-tune by niacin-GPR109A. Given acetylglutamine is coming at the highest amount of all components, I feel for the most sensitive people coming in, that it may slow down or simply conflict with the uptake and efficient processing/metabolism of the others. If we can restore all these aminos’ metabolism with less components, then it is what it is. That’s the route. With that, the updated product I would make is like a GPR109A+, which will consist of the finalized ratio of niacin-to-iron citrate (and barring folic acid if we do absolutely need it too).

Please let me know if this makes sense and how you are doing now. Thank you! Dmitry