Perfect Pregnancy
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NAD deficiency & niacin supplementation
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NAD deficiency & niacin supplementation
“supplementation with high-dose niacin before & during pregnancy prevents disease”
“embryo death & defects were specifically due to deficit of niacin-NAD in embryos; niacin supplementation prevented the disruption of embryogenesis”
https://nejm.org/doi/full/10.1056/NEJMoa1616361
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4 Replies
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“Inadequate maternal niacin intake is associated with an increased risk of congenital anomalies in the offspring.
These findings may have implications in dietary counseling and use of niacin supplementation during pregnancy.”
https://link.springer.com/article/10.1007/s00394-021-02731-9
link.springer.com
Purpose The significance of niacin in embryonic development has clinical implications in the counseling of pregnant women and may be used to inform nutrition recommendations. This study, therefore, aims to review the associations between maternal periconceptional niacin intake and congenital … Continue reading
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Just a simple thing of taking niacin (and iron ferric citrate) can defend against birth defects:
Multiple Congenital Abnormalities in the Rat Resulting from Acute Maternal Niacin Deficiency During Pregnancy
https://journals.sagepub.com/doi/abs/10.3181/00379727-112-28183
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Not only does niacin help during pregnancy to protect against birth defects/mutations– it helps maintain fertility beforehand as well:
“the researchers found that when the pregnant mother took vitamin B3, they corrected these mutations. This was seen as a “double breakthrough,” as scientists discovered both a cause and a possible solution. The cause, NAD, and the solution, niacin.”
“In this study, niacin was found to promote ovarian follicle growth, reducing the risk of oocyte apoptosis and overall infertility.3“
“niacin is required to help you maintain optimal health, supporting your fertility”
*For more about #Fertility, please see separate Fertility discussion, here in the Perfect Pregnancy Group.
imprylusa.com
Niacin, also known as vitamin B3, is both made and used by your body to convert food into energy. When it comes to niacin and prenatal health, this vitamin is required to produce Nicotinamide Adenine Dinucleotide (NAD).
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“Miscarriage and embryonic death have been associated with a deficiency in NAD+ resulting from a lack of dietary niacin in women and mice.”
” NA at a dose of 3 g daily during the follicular phase of the oestrous cycle altered the NA metabolite composition of the dominant follicle.”
https://www.mdpi.com/2076-2615/12/11/1383
mdpi.com
Supplemental Nicotinic Acid Elevates NAD+ Precursors in the Follicular Fluid of Mares
A deficiency in NAD+ has previously been linked with increased occurrences of congenital abnormalities and embryonic death in humans and mice. Early embryonic death is a major factor involved in pregnancy loss in mares, and very little is known regarding … Continue reading
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