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Dr.Kats posted an update
Two sides of the 🔑 too!
Organisms MUST supplement ample essential nicotinic acid to make enough NAD+ (proton motive force) to counter oxidative demand so that the limited as it is, also essential tryptophan (α-subunit for protein/tissue synthesis) isn’t diverted away and degraded down to NAD+ in lieu…
Without this NAD+ requirement met with nicotinic acid, resulting accruing inflammation fuels oxidative hepatic degradation of tryptophan through kynurenine ultimately as sacrifice for that NAD+ in proportion to absent nicotinic acid. Nicotinic acid protecting tryptophan for 💪🏼/🧬 is 🔑.
Nicotinic acid limiting waste of tryptophan to NAD+ is one side of 🔑. Other is most efficiently refilling that lost tryptophan by supplementing it w/ nicotinic acid at inverse of their tissue ratio so now tryptophan comes protected w/ the nicotinic acid it was burned to replace.
