AJ West
Forum Replies Created
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…more on Nrf-2
“we found that ferric iron reduced cytosolic keap-1 expression and increased nuclear Nrf-2 expression”
*this is also in the “Iron Ferric Citrate” forum*
https://onlinelibrary.wiley.com/doi/10.1002/mnfr.201700442
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…to continue with Nrf-2 which helps improve P-gP:
“we found that ferric iron reduced cytosolic keap-1 expression and increased nuclear Nrf-2 expression”
https://onlinelibrary.wiley.com/doi/10.1002/mnfr.201700442
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…here GPR109A shows improvement in Nrf2 and therefore P-gp. This beneficial effect can be seen throughout the body, as such this paper below is also referenced in the “Cancer” forum for its preventive nature in mastitis which relates to breast cancer:
“GPR109A alleviate mastitis and enhances the blood milk barrier by activating AMPK/Nrf2 and autophagy”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579459/
ncbi.nlm.nih.gov
GPR109A alleviate mastitis and enhances the blood milk barrier by activating AMPK/Nrf2 and autophagy
Mastitis causes great psychological and physical pain among women. Our previous studies found that niacin has anti-inflammatory effect, and the realization of this function depends on GPR109A. However, there are no previous reports about the anti-inflammatory ...
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Here is some more good news– the apparent no limit to cancer reducing activity of niacin:
“The benefit associated with increasing niacin intake in further reduction in cancer mortality had no apparent plateau (Supplementary Fig. 1).”
bmccancer.biomedcentral.com
Background The vitamin niacin is used as a lipid-regulating supplement, but it is unknown whether niacin has a positive influence on cancer prognosis. In this study, we examine the relationship between niacin intake and mortality among patients with cancer. Methods … Continue reading
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Here is a link to the sleep group for tips & studies:
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“Niacin beneficially affects NAFLD at 3 major stages directly”
https://pubmed.ncbi.nlm.nih.gov/31706905/
pubmed.ncbi.nlm.nih.gov
Niacin has been widely used clinically for over half a century for dyslipidemia. Recent new evidence indicates that niacin may be useful in the treatment of nonalcoholic fatty liver disease (NAFLD) and its sequential complications including nonalcoholic steatohepatitis and fibrosis. … Continue reading
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“Cryopreservation exposes sperm to physical and chemical stresses causing cell damages and impairs sperm functions.”
Even with this significant damage:
“cryopreservation generated oxidative stress, inducing sperm cryodamage, reducing progressive motility and sperm quality, as an indicator of significant chromatin/DNA damage.”
still,
“nicotinic acid induced a significant improvement in sperm parameters and chromatin quality, compared to control groups (p < 0.05).”
link.springer.com
Cryopreservation exposes sperm to physical and chemical stresses causing cell damages and impairs sperm functions. The aim of this study was to evaluate the association between motility and sperm chromatin/DNA damage before and after cryopreservation and investigate the effects of … Continue reading
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Niacin Inhibits Apoptosis and Rescues Premature Ovarian Failure:
“Over 99% of mouse and human ovarian follicles will undergo specialized cell death including atresia and apoptosis. Reduction of apoptosis may help reduce infertility and maintain the reproductive ability in women.”
“Administration of niacin to treat premature ovarian failure (POF) in mouse models showed inhibition of follicular apoptosis under harmful conditions, such as radiation and chemotherapy damage, by markedly reducing cumulus cell apoptosis.
Additionally, the number of developing follicles increased after administration of niacin.”
Niacin Inhibits Apoptosis and Rescues Premature Ovarian Failure – PubMed (nih.gov)
pubmed.ncbi.nlm.nih.gov
Niacin Inhibits Apoptosis and Rescues Premature Ovarian Failure - PubMed
Niacin may have an important function in treating POF by reducing apoptosis in clinical applications.
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“Reactive oxygen species (ROS) are of the most important detrimental factors on sperm quality during freezing process, which increases the lipid peroxidation (LPO) of cell membranes.”
As mentioned in previous comment above, niacin improves sperm quality after cryoperservation, but also:
” reduces the level of MDA and LPO of sperm membrane during freezing process, and thereby maintains the fertility potential in men with oligospermia.”
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Chronic niacin administration ameliorates ovulation, histological changes in the ovary and adiponectin concentrations:
“Polycystic ovary syndrome (PCOS) is one of the most common ovarian diseases among women of reproductive age.”
“Niacin reduced the bodyweight gain and increased ovary weights in PCOS rats. Niacin also increased the number of normal antral follicles and corpora lutea while reducing the number of cystic follicles and the thickness of theca interna.”
“this study indicates that niacin reduces cystic follicles and improves ovulation in PCOS rats.”
pubmed.ncbi.nlm.nih.gov
Polycystic ovary syndrome (PCOS) is one of the most common ovarian diseases among women of reproductive age. The reproductive and metabolic traits of PCOS are underpinned by adipocyte dysfunction, especially diminished adiponectin secretion. Based on evidence that niacin stimulates adiponectin … Continue reading
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Not only does niacin help during pregnancy to protect against birth defects/mutations– it helps maintain fertility beforehand as well:
“the researchers found that when the pregnant mother took vitamin B3, they corrected these mutations. This was seen as a “double breakthrough,” as scientists discovered both a cause and a possible solution. The cause, NAD, and the solution, niacin.”
“In this study, niacin was found to promote ovarian follicle growth, reducing the risk of oocyte apoptosis and overall infertility.3“
“niacin is required to help you maintain optimal health, supporting your fertility”
*For more about #Fertility, please see separate Fertility discussion, here in the Perfect Pregnancy Group.
imprylusa.com
Niacin, also known as vitamin B3, is both made and used by your body to convert food into energy. When it comes to niacin and prenatal health, this vitamin is required to produce Nicotinamide Adenine Dinucleotide (NAD).
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“Miscarriage and embryonic death have been associated with a deficiency in NAD+ resulting from a lack of dietary niacin in women and mice.”
” NA at a dose of 3 g daily during the follicular phase of the oestrous cycle altered the NA metabolite composition of the dominant follicle.”
https://www.mdpi.com/2076-2615/12/11/1383
mdpi.com
Supplemental Nicotinic Acid Elevates NAD+ Precursors in the Follicular Fluid of Mares
A deficiency in NAD+ has previously been linked with increased occurrences of congenital abnormalities and embryonic death in humans and mice. Early embryonic death is a major factor involved in pregnancy loss in mares, and very little is known regarding … Continue reading
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“Inadequate maternal niacin intake is associated with an increased risk of congenital anomalies in the offspring.
These findings may have implications in dietary counseling and use of niacin supplementation during pregnancy.”
https://link.springer.com/article/10.1007/s00394-021-02731-9
link.springer.com
Purpose The significance of niacin in embryonic development has clinical implications in the counseling of pregnant women and may be used to inform nutrition recommendations. This study, therefore, aims to review the associations between maternal periconceptional niacin intake and congenital … Continue reading
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Just a simple thing of taking niacin (and iron ferric citrate) can defend against birth defects:
Multiple Congenital Abnormalities in the Rat Resulting from Acute Maternal Niacin Deficiency During Pregnancy
https://journals.sagepub.com/doi/abs/10.3181/00379727-112-28183
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“Iron is essential for the normal functioning of thyroid peroxidase and iron deficiency is very commonly encountered during pregnancy.
In the present study, 68% of the females were iron deficient.
The univariable analysis found that ID [iron deficiency] was associated with an increased risk for subclinical hypothyroidism.”
cureus.com
Study of Relationship Between Iron Deficiency and Thyroid Function in Pregnant Females
Background: Iron is essential for the normal functioning of thyroid peroxidase and iron deficiency is very commonly encountered during pregnancy. Thyroid disorders and iron deficiency are associated with obstetrical and fetal complications. The aim of the study was to find … Continue reading
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“When a pregnant mother fails to consume iron supplements, iron-deficiency anaemia can develop, which increases the risks of maternal haemorrhage, the premature rupture of membranes, decreased work capacity, and maternal death (Lyoba et al., 2020).”
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“our findings highlight that elevation of serum transferrin level might be associated with a high risk of autism, suggesting a potential role of iron deficiency in autism development”
https://www.frontiersin.org/articles/10.3389/fnut.2022.957600/full
frontiersin.org
The causal association between iron status and the risk of autism: A Mendelian randomization study
Emerging evidence indicates a connection between serum iron levels and autism, but the underlying causal association is yet unclear. Thus, we performed two-sample Mendelian randomization (MR) analysis to evaluate the causal link between iron status on autism, using genetic instruments … Continue reading
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Hi Cori, I’m so sorry to hear about your husbands cancer. The “horse paste” meds are not helping at all. The best thing like you mentioned is to eat well and take the protocol. It is a hard thing to go through and a consultation with his doctors is an option as well.
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Have you seen the protocol updates & do you have the three nutrients?
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There have been thousands. We are moving trajectories over from telegram, but you can view them here for now:
T.me/TRAJ3CTORY
The best suggestion is to reduce any interfering foods, meds, and drink enough water especially when getting started. Details are on the protocol page HOM3OSTASIS.com/protocol
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This one is soothing for nice 💤
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Hi Kathryn, thank you for your concern with the cure word especially from cherry juice. We do not condone or support that statement.
I’m sorry you have had issues in the past, and thousands just like you have. To learn more about how the niacin and glutamine interact and are symbiotic, the 2nd episode of PodKats explains nicely, but it sort of long.
https://www.crowdcast.io/e/Pod_Kats/3
Right now we are working on making condensed, user-friendly courses in layman’s terms to cover specific issues as well as the mechanisms behind the protocol.
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Inhibition of SARS-CoV-2 Fundamentally Anchored by Nicotinic Acid through NAADP-regulated Ca2+ Channeling
https://www.science.org/doi/10.1126/sciadv.abl9770 -
Network Pharmacology and bioinformatics analyses identify intersection genes of niacin and COVID-19 as potent therapeutic targets – PubMed
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…also try to get recommended products because they have proven results and are reputable suppliers.
Not all products are the same and some people have had delayed results because of impurities/diluted items.
You can always tag, DM, or join weekly Newcomers Club meeting every Wednesday to check into any other products that may be easier for you to get.
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When mixing the protocol in water, as you drink you can take mouthfuls and swish it around, even let soak in a few moments/minutes to your comfort. It’s great for oral health boost & preventive maintenance!
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One of my favorites here! Listened to it every night for quite awhile. It was such a simple way to create a bedtime ritual, apply lavender lotion & play this. It became like programming to just fall asleep as soon as it started playing:
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Journaling, meditation, baths, dimming lights, all or any can be helpful as long as it is a reliable thing you can commit to & create a routine
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“Therefore, NAD+ boosters would be effective for the prevention of COVID-19 or immediately after the infection with SARS-CoV-2.”
✨Nothing boosts NAD+ like flush niacin ✨
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It seems to have a more simplified feed here. Can make this the main feed in replacement or addition to newsfeed
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@GPR109A reply here please and let’s see if this forum setup works like telegram
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I think this might be the place for the feed. The forum set up
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Hi Emanuele!
Glad you have the correct iron citrate! You will still need to take folic acid as below:
The easiest dose by preserving whole number of capsules of the three best, would be multiplying this by 4 as so:
1.125 g niacin per 1.125 mg folic acid per 1 Swanson Iron Citrate (Ferric Citrate aka Iron(III) Citrate aka Fe3+ Citrate) capsule (which is 25 mg ferric ion each capsule as shown on the back) * 4
1.125 g niacin * 4 = 4.5 g niacin
1.125 mg folic acid * 4 = 4.5 mg folic acid
1 Swanson Iron Citrate capsule * 4 = 4 Swanson Iron Citrate capsule (or 4 * 25 mg ferric iron = 100 mg ferric iron)
=
4.5 g niacin
4.5 mg folic acid
4 Swanson Iron Citrate capsules
=
9 niacin (preferably PureBulk 500mg each) capsules
4.5 folic acid (since PureBulk doesn’t make capsules, preferably Dr. Clark 1 mg capsules (I COMPLETELY FORGOT about those, which are also BOVINE CAPSULE, to get exactly half, you can weigh out the contents of one, take out half the mass, then put that back into the capsule or into another bovine gel one) but also we have Pure Encapsulations which are 800mcg each, then would be Solgar which are 800 mcg each (can also get 400mcg caps of each of these last two companies)
4 Swanson Iron Citrate capsules
So basically, most preferably:
9 niacin (PureBulk 500mg each) capsules
+
4.5 folic acid (Dr. Clark’s 1mg each) capsules
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4 Swanson Iron Citrate capsules
…
This dose, obviously, would be for those more experienced and not very first timers (unless in more serious situation)…