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83377 posted an update
Review
Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease.
Agus, A., Planchais, J., & Sokol, H. (2018). Cell host & microbe, 23(6), 716–724.
DOI: 10.1016/j.chom.2018.05.003
hmilowic7_3 Comments-
Indole is a Trp metabolite
Indole-3-propionic acid inhibits gut dysbiosis and endotoxin leakage to attenuate steatohepatitis in rats
Ze-Hua Zhao, Feng-Zhi Xin, Yaqian Xue, Zhimin Hu, Yamei Han, Fengguang Ma, Da Zhou, Xiao-Lin Liu, Aoyuan Cui, Zhengshuai Liu, Yuxiao Liu, Jing Gao, Qin Pan, Yu Li & Jian-Gao Fan
Experimental & Molecular Medicine volume 51, pages1–14 (2019)
https://www.nature.com/articles/s12276-019-0304-5?utm_source=perplexity
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These in vivo and in vitro!!!!!
You cannot administer IPA…
But you can administer ORAL Trp
The header should read
Tryptopan inhibits gut dysbiosis and endotoxin leakage to attenuate steatohepatitis in rats with its metabolite IPAI hate AI
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@83377 All pathways with the capacity to make IPA use Trp as a foundational substrate.
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