The below was disseminated to a member in their specific case, note, but I believe it applies to all while in general in terms of biology. Hence, I am relaying it below in hopes of getting more needed attention to https://HOM3OSTASIS.com/InfinaLife :

Why IV / “pre-made” NAD feels so strange

NAD⁺ inside the body is not really a nutrient; it’s an internal cofactor that your cells continuously break down and rebuild from smaller precursors.

When you infuse NAD⁺ in a vein, your cells do not simply absorb it intact and snap it into place. Most of that IV NAD⁺ has to be broken apart at the vessel wall and in the circulation, and then reassembled via the same enzymatic machinery that was already struggling in the first place. So IV NAD⁺ is like dumping assembled engines into a factory whose bottleneck is metal and workers, not finished engines. The system gets hammered with a pharmacologic load, which is exactly why a lot of people feel awful and can’t tolerate the drip.

The real solution, in my view, is to remove the bottleneck on your own ability to make and recycle NAD⁺, not to force-feed the finished molecule.

Why I center everything on nicotinic acid (NA)

Among the various “vitamin B3” forms, nicotinic acid is the classic, direct vitamin precursor that feeds new NAD⁺ (and NAADP⁺) synthesis. The other B3-type compounds – niacinamide, NR, etc. – can contribute, but they are more dependent on additional conversion steps and rate-limited salvage enzymes, which are exactly what get stressed in chronic inflammation and disease.

Nicotinic acid is the form that most cleanly expresses the “vitamin” property here: when you give enough NA, you give cells unrestricted substrate to build NAD⁺ and NAADP⁺, without leaning so heavily on those already-strained salvage loops.

So your pattern – no benefit from oral/nasal NAD, can’t tolerate IV NAD, but do fine with NA – is exactly what I would expect. Your system is saying: “Let me build NAD⁺ myself from a proper vitamin precursor; don’t shove the finished nucleotide into my bloodstream.”

What InfinaLife actually does (NA + proportional free L-tryptophan)

InfinaLife is built around two pieces working together:

1. Nicotinic acid (NA) as the heavy lifter for NAD⁺ and redox;

2. A small but precisely proportional dose of free-form L-tryptophan, riding alongside the NA.

That free-form tryptophan is the “signal” piece. Here’s what that means in practice.

1. Before InfinaLife: chronic tryptophan drain into oxidative degradation

In modern chronic inflammatory states, the body tends to:

• Be short on NAD⁺, and

• Respond by driving tryptophan hard through oxidative degradation in the liver (the kynurenine pathway).

In textbooks that pathway is often framed as a way to “make NAD⁺ from tryptophan,” but under chronic stress that’s not what really happens in a useful way:

• Large amounts of tryptophan are pulled into the liver and oxidized / broken down,

• A lot of that flux stalls in intermediate, oxidative catabolites,

• You get depletion of tryptophan and accumulation of these degradation products,

• Without a proportionate, clean rise in NAD⁺ to show for it.

So practically, a lot of the tryptophan you eat is being siphoned into a degrading, oxidative sink in the liver in an attempt to cover NAD⁺ needs, but it doesn’t actually restore NAD⁺ efficiently. You lose the tryptophan and don’t really fix the NAD⁺ problem.

That means:

• Free tryptophan pools inside cells stay low and tightly guarded,

• Less is available for protein repair, serotonin, melatonin, etc.,

• You live in a state of both NAD⁺ shortfall and tryptophan depletion.

2. First move: NA supplies NAD⁺ directly and “clears the backlog”

When you take InfinaLife, the nicotinic acid component:

• Directly feeds new NAD⁺ synthesis via the proper NA pathway,

• Improves the NAD⁺/NADH redox balance,

• Begins to relieve the pressure that was forcing tryptophan into that oxidative degradation sink.

In other words, NA steps in as the appropriate, high-capacity substrate for NAD⁺, and over time:

• The body no longer needs to shove so much tryptophan into that dysfunctional degradation route,

• The system can gradually “clear” that overload state where tryptophan is being wasted in the liver without solving the NAD⁺ problem.

3. Second move: the proportional free-Trp dose as a signal

On top of that, InfinaLife gives you a small, carefully scaled dose of free-form L-tryptophan, tied proportionally to the NA dose.

That matters because:

• This is unbound, free tryptophan, not slow-release protein-bound Trp.

• It reaches the bloodstream and liver as a clean, immediate free-Trp pulse right when NA is supplying robust NAD⁺ substrate.

To the system, the combined state – “NAD⁺ demand is now properly met by NA” + “free Trp is actually present and not scarce” – is interpreted as:

“We are no longer in a tryptophan-depletion emergency.
We do not need to keep pushing tryptophan into that oxidative degradation track.”

Mechanistically, that tends to:

• Downshift the drive to keep oxidizing Trp in the liver just to chase NAD⁺,

• Reduce the chronic flux of Trp into those degradation products,

• Shift the balance from catabolism → anabolism with respect to tryptophan.

That’s the “signal”: the free-Trp fraction, when it arrives alongside adequate NA, is a clear biochemical message that the old pattern – “drag Trp into the liver and burn it up while still not fixing NAD⁺” – can be switched off.

4. What happens to the rest of the tryptophan you eat

Once NA is covering NAD⁺ properly, and the free-Trp pulse has told the system to back off the oxidative sink, something important changes:

• The tryptophan you get from normal dietary protein – which previously was getting pulled into the liver and degraded – can now increasingly be preserved and redirected to its intended roles:

  • Protein synthesis and tissue repair,

  • Serotonin → melatonin (mood, circadian rhythm, sleep),

  • Other constructive pathways that were starved when Trp was chronically treated as sacrificial fuel.

So InfinaLife is not “just more tryptophan.” It is:

• NA: supplying NAD⁺ directly and displacing the need to waste Trp in oxidative degradation,

• Free-Trp (in a controlled ratio): providing the signal that Trp is no longer to be sacrificed like that,

• Together: shifting your whole tryptophan economy from a degrading sink → restored, anabolic use.

Why I want you to skip more NA/AA and move straight to InfinaLife

The original NA/AA combo (nicotinic + ascorbic acid) came from an older view where some of the “vitamin C benefits” were likely indirect niacin benefits – vitamin C helping niacinamide-type scraps feed back toward nicotinic acid and NAD⁺. That made sense when nicotinic acid itself wasn’t being pushed hard, and when the full NA story wasn’t clear.

The flip side we now see is:

• Ascorbic acid interacts chemically with the same nicotinyl ring that both niacinamide and nicotinic acid share.

• At higher levels, this means ascorbic acid can interfere with nicotinic acid’s own smooth conversion into NAD⁺, exactly where we want a clean, high-capacity flux.

Given that:

• You’re precisely the phenotype that does poorly with forced NAD⁺ and best when NAD⁺ is built endogenously from NA, and

• We now have a formulation (InfinaLife) that couples NA with the right amount of free-Trp “signal”,

…it’s simply a better use of your time and biology to transition fully to InfinaLife rather than keep pouring money into NA/AA.

To soften the financial hit for members who previously bought NA/AA (and/or any previous formulations coming in), I’m effectively doing a buy-one-get-one on the first InfinaLife order (doubling the amount on that first shipment) so this pivot isn’t punished financially.

In short:

• IV / pre-made NAD⁺ overloads the system without fixing the bottleneck.

• Nicotinic acid fixes the bottleneck by restoring NAD⁺ from the proper vitamin precursor.

• Under chronic stress, tryptophan is mostly being dragged into oxidative degradation in the liver, not productively turned into NAD⁺.

• The small, proportional free-Trp fraction in InfinaLife is the signal that lets the body stop wasting tryptophan this way and reallocate it back into serotonin, melatonin, and protein synthesis.

• That’s why I’d rather have you not finish what you already have, and instead just move fully onto InfinaLife and let that NA + Trp pair do what your IV NAD never could.