-
Role of methionine in nocturnal melatonin peak in the pineal gland
“Methionine dose-dependently stimulated O-methylation of hydroxyindoles in the pineal gland and contributed to the nocturnal melatonin peak in adult male Wistar rats. Methionine is involved in the maintenance of diurnal rhythms by regulating biochemical transformations of indoles in pinealocytes. Our findings provide theoretical basis for new applications of methionine.”
https://pubmed.ncbi.nlm.nih.gov/15455109/
…
pubmed.ncbi.nlm.nih.gov
Role of methionine in nocturnal melatonin peak in the pineal gland - PubMed
Methionine dose-dependently stimulated O-methylation of hydroxyindoles in the pineal gland and contributed to the nocturnal melatonin peak in adult male Wistar rats. Methionine is involved in the maintenance of diurnal rhythms by regulating biochemical transformations of indoles in pinealocytes. Our … Continue reading
3 Comments-
…
Methionine Adenosyltransferase:Adrenergic-cAMP Mechanism Regulates a Daily Rhythm in Pineal Expression
https://www.jbc.org/article/S0021-9258(20)76635-4/fulltext
“The results presented indicate that MAT II is the only MAT isoform expressed in the pineal gland, as is the case in all tissues examined, other than the liver. MAT2A expression in the pineal gland, as judged by mRNA abundance, is notable for two reasons: 1) the marked nocturnal increase in mRNA levels and 2) the level of mRNA achieved at night is manyfold higher than expression in other tissues. Both of these characteristics (rhythmic expression and high levels of expression in the pineal gland) are not surprising in view of the central role of SAM in melatonin synthesis and the daily rhythm in synthesis.” -
Oooh yes – and for the R-lipoic acid to start clicking to help that too (to make acetyl coA) and into niacin… there is dose response benefit with methionine being so deficient so don’t short yourself
-
But note – likely won’t need as much lipoic as before! Please see updates in Group!
-
-
