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Q&A Session (Aug 10, 2025) — Member Questions
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Q&A Session (Aug 10, 2025) — Member Questions
I think it will be smoothest for members if — whether or not you can make it to the live Q&A session (Aug 10th at 9 PM EST) — post any question(s) you may have coming in, so that I can answer them live for members to listen to live &/or come back after to review recording. In this way, here in this Discussion thread, we can also discuss the answers after and provide further follow-up together!
Of course, members can ask questions not in this Discussion thread that may come up (or who didn’t have time to post them here before) during the live Q&A session.
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14 Replies
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10/7/25
Hi Dmitry
Would you be able to answer these questions for the Q&A please.
Cheers Jim
How do we know when we are at a proflaxas stage, and how frequent would you dose and quantity ?
What effects would a two minute, zero degrees ice bath daily have on taking this ?
What are the priority foods and drinks to eliminate from diet and high in phenols etc,
I’m aware of Eggs broccoli coffee tea alcohol ?
How long to detoxify vax ingredients and other toxins etc in general if taking higher doses with right foods exercise ?
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“How long to detoxify vax ingredients and other toxins etc in general if taking higher doses with right foods exercise ?”
Immediately!.
The detox that they tell you to have to take all the time, is a scam and just money making.
Detox only an emergency medicine belongs to ER.
You detox in ER from poison/toxin/venom and released same day.
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since vitamin C “is a non toxic, non specific antitoxin it may be used for any type of venomous bite without having to await identification of the culprit”Ascorbic acid inhibited 100% of the proteolytic activities of B. moojeni and B. alternatus on azocasein, at 1:10 ratio, the effects of all the venoms on fibrinogen, the hemagglutinating activity of B. jararacussu venom, and also extended the plasma coagulation time induced by all venoms analyzed.
Inhibitory effects of ascorbic acid toward snake venom metalloproteinase (SVMP) from Indian Echis carinatus venom: Insights from molecular modeling and binding studies.
Choudhury M, Senthilvadivel V, Velmurugan D. J Biochem Mol Toxicol. 2018 Dec;32(12):e22224. Epub 2018 Oct 1. PMID: 30276921.
DOI: https://doi.org/10.1002/jbt.22224
Niacin & Tryptophan: Repair and regenerate DNA. This takes longer time
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I will touch on these notable points DA makes too, but on this note, remember that “toxicity” itself was originally defined (by Krehl) as what increases requirements for NAD+ essentially… this underlying theme of NAD+ regeneration is core here, as I will touch on in greater detail during the Q&A!
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“How do we know when we are at a proflaxas stage, and how frequent would you dose and quantity ?”
prophylaxis/maintenance are pharmaceutical and supplement companies marketing terms
Why wait to know when, and why not just feel good all. CNT is cheap and safe to stay at high doses all time and feel good all time-
Yes, this is a solid strategy given the prolific safety … this IS safety without really any upper limit / “too much” … but at the same time, I will try to address how we can more informatively track this, which many want that reassurance
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“What effects would a two minute, zero degrees ice bath daily have on taking this ?”
TRPV1 is primarily a heat and capsaicin-activated receptor.Cold Suppresses Agonist-induced Activation of TRPV1
https://doi.org/10.1177/0022034511412074Nicotinic Acid is a Common Regulator of Heat-Sensing TRPV1-4 Ion Channels
https://doi.org/10.1038/srep08906Nicotinic Acid Activates the Capsaicin Receptor TRPV1 – A Potential Mechanism for Cutaneous Flushing
https://doi.org/10.1161/ATVBAHA.113.303346TRPV1 Channels Are Involved in Niacin-induced Cutaneous Vasodilation in Mice
https://doi.org/10.1097/FJC.0000000000000181
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Got it!
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I have similar questions to Jim regarding food and drink, doses and perhaps a guideline for how to determine daily maintenance. What signs are there that we should need a higher than maintenance dose for intervention?
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Excellent Question, Anna! I will delineate these key points during the Q&A as well!
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Hi Doc,
Recent bloodwork shows low folate while taking 2 g nicotinic acid daily (plus vitamin C and tryptophan). ChatGPT tells me that niacin can increase folate demand…
In this situation, would you recommend supplementing folic acid (it used to be in the protocol once upon a time) and if so, at what dose and for how long?
Thanks for your work and time.
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ChatGPT is drunk and a liar
Only in a theoretical basis impacting folate (methyl doner) demand through its role in methylation.
No evidence from studies or RCTs supporting that.
Meanwhile…Several human experiments have confirmed the role of vitamin C in protecting reduced forms of folate from oxidation.
Vitamin C can positively influence folate levels in the body by protecting it from oxidation and potentially aiding in its absorption. Specifically, vitamin C can help prevent the breakdown of reduced forms of folate, ensuring they remain available for use in the body, and may also improve the conversion of folate in food into a form the body can readily absorb
https://bmchematol.biomedcentral.com/articles/10.1186/s12878-018-0107-2L-ascorbic acid improves the serum folate response to [an oral dose of [6S]-5-methyltetrahydrofolic acid] [folate in food] in healthy men
https://pubmed.ncbi.nlm.nih.gov/17622258/
bmchematol.biomedcentral.com
Background In 1962 Victor Herbert developed megaloblastic anaemia four months after commencing a severely folate-deficient diet whereas, in his self-experiment 50 years later, this author took 19 months to fully deplete his liver folate store. This author proposed that his … Continue reading
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Yes, I will address this during tonight’s Q&A too. But for prelude: ha, AI–unless programmed better–will invariably off the jump misnomer niacinamide as “niacin”. Niacinamide–unlike nicotinic acid = actual niacin–will lead to more demand of folate, given the extra methylation needed to de-amidate niacinamide to become actual niacin aka nicotinic acid to then turn to NAD+. Without enough C and/or tryptophan meanwhile with sufficient nicotinic acid going, depending on niacinamide to turn to niacin then NAD+ more will demand more methylation in this way in turn. However, niacin will not have this problem, and all folate (which is not supposed to be exogenously supplemented in the first place, but endogenously cycled via sufficient amounts of these three identified nutrients in CNT) will be restored as DA showed above with the triad of the three in proper ratio ideally as we have.
When was your blood test taken which showed folate still low in terms of when you started added tryptophan to C and (actual) niacin in proper ratio?
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Let’s not forget other Methyl donors, not only folate
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We don’t need methyl donors… we need efficient NAD+ … all those listed in the above Table are endogenous metabolites
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