Weight issues
Discuss how protocol can help with weight gain or loss, depending of the issue.
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Regaining loss mass
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Regaining loss mass
Am about 20lbs lighter than I was prior to my health issues. Around 13 lbs of muscle lost with 7 lbs of fat. Although I now lift weights more optimally and with greater intensity than before. Any advice except for the obvious of eating more?
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12 Replies
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Hello Jon. Are you taking the proper N-acetyl L-glutamine per the finalized https://HOM3OSTASIS.com/Protocol, with flush niacin, and NOT the preceding less-stable, slightly improper free l-glutamine (with flush niacin)?
Also, could you please give me a bit more detail on the dosing and your dimensions/activity levels prior to these recent revelations?
Thank you!
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Took 10g Niacin + 15g NAG yesterday over like 15 doses and felt a bit better and less tired/depressed. Will keep it up and report back. I barely even flush anymore.
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Honestly don’t even care about getting the weight back as long as I can resolve the fatigue and improve focus
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Yes just started the protocol a week ago with PureBulk flush Niacin & NALG from Bulksupps. I take around 1.5G & 2,250 respectively split by 3 doses. Previous dimensions were 198cm barefoot 205lbs naked. Current is 185lbs. Low BF. Played college athletics, post graduation struggled with depression and lack of productivity which has gotten worse over time. Was put on many meds, many dopamine centered. Still take some but trying to take less. Have started re engaging in cardiovascular sport since starting protocol and feel better, but still feel like I only have a portion of the gas I used to, but same motivation which is frustrating.
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So this dopamine depletion over life goes side-by-side with flush niacin’s lack (to fuel so many things including literally all of dopamine per the 0.96 significant correlation coefficient in the below recent paper that showed how in-line flush niacin deficiency is in chronic fatigue), and then not addressing this developing flush niacin/NAD+ deficiency with needed supplementation over the life course thereafter (and of course before recognizing this) will lead to the niacin receptor becoming growingly exposed to inflammation/oxidative stress into literally getting damaged/disabled/burned out, in turn limiting flush niacin to restore NAD+ solo. <- Because as this happens and the demand for NAD+ (proton motive force to keep energy current into, through, and out cells to make ATP going) grows further, glutamine accordingly grows increasingly deficient in then being readily available (and in growing need more) to process more needed NAD+ as these sequelae unfold more unaddressed.
“Niacin and DA levels of the patient group were significantly lower than those of control group (p=0.003 and p=0.02, respectively). A very strong positive correlation was found between niacin and DA levels (r=0.96 p<0.001).”
Evaluation of clinical relationship of serum niacin and dopamine levels in patients with fibromyalgia syndrome
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305637/^ Since flush niacin’s established anti-inflammatory causal therapeutic powers — to restore energy metabolism in cells and ultimately health in the host — to happen most efficiently are contingent directly upon the degree of the expression of its GPR109A receptor of each cell corresponds in-line to (and not short of) indeed how much inflammation, free radicals, cellular debris, gunk, pathogens, particles, toxins, etc. there are in the cell, signaling to niacin to bind to it to come into the cell and fully address + provide proton motive force/H+ (from the bigger molecules, NAD+ and NAADP, exclusively niacin, catalyzed by available glutamine, makes without rate limit) to keep the cells going thereafter, not addressing the growing niacin/NAD+/NAADP+ deficiency over the life course, especially upon worsening health status &/or over aging, will side-by-side lead to available glutamine deficiency concordantly, rendering the need for available glutamine that diet can no longer fulfill to be supplemented with flush niacin. The below collection of papers can explain why you may have in fact been a bit overweight (respective to what would have been a more ideal weight), how you despite engaging in college sports-level activity were still not getting the most out of the exercise or yourself out into the exercise performance, as well as (along with this dopamine deficiency in-line with niacin’s) the depressive symptomatology manifesting over the meanwhile.
“The present study reported that higher BMI was causally associated with lower glutamine levels. Both obesity and downregulation of glutamine were causally linked to depression.”
Causal Association Between Obesity, Circulating Glutamine Levels, and Depression: A Mendelian Randomization Study
https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgac707/6889636?login=false
Niacin fine-tunes energy homeostasis through canonical GPR109A signaling
https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fj.201801951R
Nicotinic Acid Improves Endurance Performance of Mice Subjected to Treadmill Exercise
https://www.mdpi.com/680136The Effect of Substrate Utilization, Manipulated by Nicotinic Acid, on Excess Postexercise Oxygen Consumption
https://sci-hub.ru/10.1055/s-2007-972600Niacin Beneficially Alters the Secretion of Intestinal HDL in a Rat Model of Insulin Resistance by Opposing Effects on PPAR Alpha and TNF Alpha
https://www.ahajournals.org/doi/10.1161/atvb.34.suppl_1.629…
With all that, have you gotten to higher doses of flush niacin + N-acetyl L-glutamine? As someone more fit, trained, and physically/energetically active over life up to this point and especially now trying to get back into the groove (& what you will see, already are seeing but don’t realize it yet fully, will be further gains), you are going to need higher doses, even if you were ideally healthy, but especially from the get-go for therapeutic purposes from a non-niacin-supplemented life coming in and simultaneously to take further advantage of the (especially cumulative) additive (potentially even synergistic) benefits of what engagement in leisure-time physical activity can further provide on-top. Already you are experiencing the preliminary reduction of now how many decades of extra mass/energy (of let’s just imagine it’s just diet we are talking about here) accruing through the ins and outs through your body and liver — paramountly the accumulating stores of fat deposits in the liver (dumping in there from what is extracted from diet for the liver to make ATP) that remain not able to make ATP to any ideal pace to not accumulate over age no matter what we do if it’s not supplementing niacin, thereby limiting VLDL-TG secretion out when too much overload of this fat develops in the liver, and effectively comprehensively through circulation, minimizing the need to continue to have fat (even carbs support fat when fat becomes too overloaded in liver) have to accumulate to support ATP requirements as we age.
Exclusively nicotinic acid, (flush) niacin through its innate GPR109A receptor does what exercise does mechanically spot-on first of all, in that by through its endothermic processing turning to bigger molecules, NAD+ & NAADP+, at-will if provided with adequately available glutamine catalyzing this biosynthesis in cells, we readily start burning and limiting the propagation of excess fat through our body by providing the potential energy simply via niacin continuing to the physically bigger molecules, NAD+ and for proper phagocytosis/clearance of particles, even bigger, NAADP+, and without limitation of these conversions’ rate (if niacin, acetylated glutamine, clean water, & decent-enough diet are sufficiently supplied) BUT without having to invest any work/potential energy and thus ATP. If relying on strictly exercise engagement as the only actually other feasible strategy to expend (especially cumulatively via consistent engagement over decades) clinically relevant levels of excess energy from accumulating instead of relying on only the flush niacin-deficient diet w/o exercise activity participation (i.e., even worse / the general population aka the “control”), those more persistently physically active during leisure-time will still imminently, once each of them reach a certain number, X later age, not physically be able to prevent progression to a threshold level of accumulation of fat in/through the liver and overload through the body. Simply, without niacin-GPR109A going via sufficient supplementation of flush niacin + N-acetyl L-glutamine, trying to sustain biological function in such a fashion via “stores” of energy sooner or later results in the liver fattening, inflammation + ROS/RNS propagating, into further clinical conditions, disability, frailty, and disease over the life epoch (and concordantly or eventually, if without obesity or any extra weight, into the erosion of our bone marrow, with it, even DNA & RNA, being burned off to provide ATP, as the glutamine availability runs out more & more over life), we will try to recoup/store with diet later). We cannot rely on solely exercise (on top of well-balanced, decent diet), given the fact that not only is the magnitude of the energy expenditure from even the most intense possible exercise meager compared to the potential energy a single niacin-GPR109A dose provides and so we get dramatically less release of energy through exercise, but even further, we have to actually perform increasing amount of work with exercise to expend this much relatively less release of energy? With mechanical/kinetic body movement to burn the fat, that is (more intense, if trained to) physical activity, we try to put the FFAs into literally enough acute movement to release the potential energy stored in their previously in-tact/idle bonds. Meanwhile, swallowing and bowel movement is literally minimal work, and for perhaps thousands times of output energy expended per intense exercise bout. And the cherry on top, with sufficient niacin/acetyglutamine/GPR109A going, we do not have to recoup (any amount of any) ATP that was initially provided through the investment for it by the mechanical work of effort-intense exercise.
What this means is that a life characterized by initiating and preserving adequate supplementation of niacin/NAG, i.e., dynamic maintenance of modulated/regulated GPR109A, could be perceived as one that can remain (or if after the fact of not starting life supplementing, first recoup to then assume the ability to then remain) in a state towards persisting in thermodynamic equilibrium of energy transferred in, out, and through (all the cells as parts and a simultaneously, a sum of them, of) the organism system (that is, you, attached to the ecological outside environment universe of limitless energy source).
What I think is going on in your individual case, is that you are dosing too low (and to a degree, not often enough) still, particularly at this point of trying to shift to ideal health into gains from exercise on top. To this point, with lower dosing, you have been observing literally the burning-off and clearance of the excess mass/energy aforementioned (i.e., predominately the accumulated stores of fat incoming), given your weight is dropping and simultaneously you are likely also not having to eat as much meanwhile not to forget, having to support further this more intense activity participation. However, at the same time, you are not leaving much extra niacin-GPR109A to harness their further abilities to have you quite energized and consistently, into finally getting the most out of exercise. Being 190 lbs necessitates a bit higher dosing versus average 150 lb adult at this point (and maintained for a bit more and a bit higher thereafter relatively versus average adult for health maintenance) to support just basal metabolic rate and so definitely even more to support exercise gains whilst expecting to remain energized through the days then even more so further.
Lastly, I do think it is worth considering this: https://t.me/c/1804009892/6041
Please let me know if this makes sense…
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Thank you for your response Dmitry. This does make sense. I am the same person who in the telegram chat asked about the NAG coming first to get the flush as the flush has now subsided even at higher doses. Im planning to continue to take around 10g N and 15NAG daily as I’ve done past two days let you know how it goes.
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https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=video&cd=&ved=2ahUKEwjruJfA49z-AhX1mmoFHT9sCx8QtwJ6BAgGEAI&url=https%3A%2F%2Fthechalkboardmag.com%2Fniacin-b3-supplement-for-depression-anxiety%2F&usg=AOvVaw13gbbsZrz-E9OiybNVVWXe This is where I got the idea to take around 10G Niacin from, if you think I should try more let me know, as I’ve taken 9 today so far, even with NAG before, with 0 flush. I read from Hoffer if you take a lot and don’t flush then you need it the most. Thank you
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How are you feeling so far after a few days, Jon?
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Should we be measuring our dopamine levels?
Also do you recommend any other protocols to elevate dopamine?
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WHAT OTHER PRODUCTS?!?! DO YOU THINK I HAVE NOT CONSIDERED “OTHER PRODUCTS” OR SOMETHING?!?!?
“Niacin and DA levels of the patient group were significantly lower than those of control group (p=0.003 and p=0.02, respectively). A very strong positive correlation was found between niacin and DA levels (r=0.96 p<0.001).”
Evaluation of clinical relationship of serum niacin and dopamine levels in patients with fibromyalgia syndrome
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LET ME MAKE THIS CLEAR: A 1.0 CORRELATION MEANS THEY ARE LITERALLY DIRECTLY GOVERNED BY THE SAME EXACT MECHANISM 1-TO-1 … 0.96 CORRELATION BETWEEN FLUSH NIACIN AND DOPAMINE LEVELS …
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If you are gonna come in here, still not having even tried a drop of the only actual medicine, flush niacin + N-acetylglutamine, and already asking for “other products,” then it is clear to me that you have nothing here to bring for anyone but trying to discourage them from healing. Is that the case?
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