Early-life antibiotic dysbiosis impairs microbial tryptophan-nicotinic acid metabolism exacerbating food allergy in adulthood

https://www.sciencedirect.com/science/article/pii/S1567576925008781

• Early Antibiotics Elevate Food Allergy Risk: Disrupt gut microbiota and tryptophan metabolism, increasing susceptibility.

• NA Deficiency Compromises Barrier/Immunity: Antibiotic-driven dysbiosis lowers nicotinic acid (NA), impairing intestinal integrity and Th2/Treg balance.

• NA Supplementation Prevents Allergies: Restores barrier function and immune homeostasis via GPR109A, countering antibiotic-associated food allergy.