^ Also, I want to reassure you that any early heart rate &/or blood pressure fluctuations that seem erratic are in fact flush niacin (powered by equimolar glutamine) trying to repair your microvascular architecture but just not having enough (and sometimes just a bit too much – like if above the 2.5 g + 3 g N + G dose for the first time) dose each dose to start or dosing prolonged yet to have repaired all your vascular tissue to make it smooth just yet. On top of this, you can add the whole surprise / novelty factor of finally getting real medicine and starting to get more ATP made more easily out of nowhere, which can be startling, even subliminally a bit unsuspecting to say the least, leading one to be a bit subliminally then panicky and the heart rate jump. However, please note – that this is literally just temporarily for a few minutes and the first few times. Nevertheless, as proved in various trials now, at the conclusion of these early sessions with usually not enough dosing just yet to have made it more comfortable (or too much the very first time and it being overwhelming acutely in that sense), where the heart rate is emperically shown to increase, these are temporary increases (again, likely mainly due to the shock/novelty factor) that then cool down within minutes and resolve back normal within an hour. You have to build back your microvascular architecture to have it all smooth again acutely like the college males in the below trial also linked… flush niacin + equimolar glutamine at sufficient (but not too overwhelming like beyond 2.5 + 3 g for adults that first time) dosing allows this to happen more expeditiously and smoothly. And again, this complaint in the beginning is a result in itself of the damaged microvascular tissue as a result of the lack of niacin + glutamine to have protected it, with the only way now to repair being to restore the niacin + glutamine. So it’s a good Catch-22. Please check out the excerpts from these aforementioned trials showing all this. Per the second one, with continued sufficient dosing, we will eventually get like these college kids to have even 1 g niacin (with equimolar glutamine) acutely improve our BP and HR (if needed right then) and ultimately keep it modulated at ideal levels as we keep dosing. However, to do that, we have to replete the niacin + equimolar glutamine forward. The fluctuations you will see will minimize forward with dosing accordingly…

“Immediately after drug instillation, an increase in pulse rate (maximum 45%) and blood pressure (maximum 20%) appeared, indicating rapid absorption. The pulse rate was normalized after 20 min. The increase in blood pressure, however, was ultimately followed by a decrease and normalized after 20-50 min. “

GI Absorption of Niacin in Humans
https://sci-hub.ru/https://doi.org/10.1002/jps.2600660635

“Resting systolic blood pressure (mmHg) was significantly decreased from baseline (124.7±11.9) at 30 min (120.6±10.5), 40 min (120.3±12.7), 50 min (120.8±14.9), 60 min (119.3±12.4), 70 min (117.9±12.6), 80 min (118.5±11.9, and 90 min (119.4±8.9) post-consumption. Resting diastolic blood pressure (mmHg) was significantly decreased from baseline (77.8±9.1) at 20 min (75.8±7.4) and at 80 min (74.7±10.8) post-consumption. Resting heart rate (bpm) was significantly decreased from baseline (71.3±11.3) at 20 min (67.5±12.2), 30 min (68.2±13.2), 40 min (66.7±12.5), 50 min (65.7±12.5), 60 min (66.2±11.4), 70 min (67.8±11.6) and 90 min (67.8±12.6) post-consumption.”

THE EFFECTS OF ACUTE NIACIN SUPPLEMENTATION ON RESTING HEART RATE AND BLOOD PRESSURE IN COLLEGE-AGED MALES
https://digitalcommons.wku.edu/ijesab/vol11/iss4/41/

I’m sorry as I am just seeing this. I didn’t know how the message system worked. Thank you so much for the follow up. I felt a bit of anxiety last night as yesterday I took equimolar doses niacin 2 and then 1 and then 2.5.
I felt a bit anxious overnight. I am using distilled water but I also take melatonin and magnesium to help with sleep.
Today my gut is off.