Ivermectin Injured
For anyone who did the Ivermectin protocol and stopped. I started the ivermectin protocol in January... View more
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IVM recovery & prevention
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IVM recovery & prevention
Due to the massive increase in COVID 19 drugs being used, these drugs are overwhelming water systems and are ending up in the drinking water supply giving exposure to those not taking any medications. The closer to retirement homes and hospitals the worse it is.
For those that have taken ivermectin the impact is even worse and may be clear and apparent at this point. Because there are different levels of P-gp expression– which helps remove and keep ivermectin (and other nondesirable chemicals/prescription drugs/other exposures) out of the CNS and from crossing the BBB, it would be wise to help improve the condition of your MDR1/P-pg pump.
*Please see below on how HOM3OSTASIS protocol would help and also check the GUT & IBS forums for crossover information that have additional information that can help even more*
“Butyrate may activate G-protein coupled receptors (GPCR) on the cell surface [11, 41, 51,52,53], or signal through transcription factors including nuclear factor erythroid 2-related factor 2 (Nrf2) [54].
Activation of Nrf2 and PXR by agonists have been shown to increase P-gp transcription [55,56,57,58].”
“the intestinal microbiota is required for governing the expression of P-gp in the colon”
https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-021-01137-3
microbiomejournal.biomedcentral.com
Background P-glycoprotein (P-gp) plays a critical role in protection of the intestinal epithelia by mediating efflux of drugs/xenobiotics from the intestinal mucosa into the gut lumen. Recent studies bring to light that P-gp also confers a critical link in communication … Continue reading
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3 Replies
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…to continue with Nrf-2 which helps improve P-gP:
“we found that ferric iron reduced cytosolic keap-1 expression and increased nuclear Nrf-2 expression”
https://onlinelibrary.wiley.com/doi/10.1002/mnfr.201700442
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…here GPR109A shows improvement in Nrf2 and therefore P-gp. This beneficial effect can be seen throughout the body, as such this paper below is also referenced in the “Cancer” forum for its preventive nature in mastitis which relates to breast cancer:
“GPR109A alleviate mastitis and enhances the blood milk barrier by activating AMPK/Nrf2 and autophagy”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8579459/
ncbi.nlm.nih.gov
GPR109A alleviate mastitis and enhances the blood milk barrier by activating AMPK/Nrf2 and autophagy
Mastitis causes great psychological and physical pain among women. Our previous studies found that niacin has anti-inflammatory effect, and the realization of this function depends on GPR109A. However, there are no previous reports about the anti-inflammatory ...
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…more on Nrf-2
“we found that ferric iron reduced cytosolic keap-1 expression and increased nuclear Nrf-2 expression”
*this is also in the “Iron Ferric Citrate” forum*
https://onlinelibrary.wiley.com/doi/10.1002/mnfr.201700442
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