[Dr.Kats]

So which dose ratio are you doing exactly of the GPR109A capsules to Swanson iron citrate capsules (assuming you have this Swanson iron citrate: https://www.swansonvitamins.com/p/swanson-premium-iron-citrate-25-mg-60-veg-caps)? It looks to be best at 5 GPR109A Capsules (which is 1,250 mg or 1.25 g flush niacin worth) with every 1 Swanson iron citrate capsule (25 mg “iron” on the back). I know we had it way too high at first (at even flipped, 4.5 Swanson iron citrate capsules per 1 GPR109A capsules), but we had no reference point to go off. We now know it’s way closer to and may be right around 5 GPR109A capsules (1.25 g niacin) per 1 Swanson iron citrate capsule (25 mg “iron”). Let me know which ratio you were doing…

Also, along with the Swanson Iron Citrate capsules, do you happen to have solo, separate products of flush niacin by Pure Bulk (whether in capsules or powder) and folic acid by Pure Bulk (or someone else, but make sure it is only folic acid and not methylfolate), separately? It is worth trying niacin + iron citrate in ratio of 1.25 g niacin + 25 mg “iron” (i.e., 1 Swanson iron citrate capsule) OR niacin + folic acid + iron citrate in ratio of 1.25 g niacin + 1.525 m(illi)g(rams) folic acid + 25 mg “iron” (i.e., 1 Swanson iron citrate capsule) — that is, without the acetylglutamine. Per what we are learning about iron citrate, especially some of these brand new papers, it looks like the dysregulation of glutamine/amino acids metabolism (and the lack of that little bit of folic acid) may be subordinate endogenously to namely the iron (citrate) and niacin deficiency, in that restoring simply iron citrate with niacin (ideally at ideal stoichiometric ratio together, whatever that exactly is, but it looks to be no less than an amount of 1.25 g niacin (which note is 2.5 Pure Bulk flush niacin 500-mg each capsules) per each 25 mg “iron” (i.e., 1 Swanson iron citrate capsule). I believe supplementing ANY kind of amino acids (including even acetylglutamine and especially the heat-labile free l-glutamine as we saw before) may be worthless to supplement, especially during a pellagra (which looks to be namely a niacin + iron (citrate) deficiency, potentially folic acid too, but I believe we can circumvent it), as again, it is seeming to be uncovered that all amino acids’ metabolisms, including glutamine/glutamate’s (the most important/regulating of all amino acids) are regulated by iron status, modulated in fine-tune by niacin-GPR109A. Given acetylglutamine is coming at the highest amount of all components, I feel for the most sensitive people coming in, that it may slow down or simply conflict with the uptake and efficient processing/metabolism of the others. If we can restore all these aminos’ metabolism with less components, then it is what it is. That’s the route. With that, the updated product I would make is like a GPR109A+, which will consist of the finalized ratio of niacin-to-iron citrate (and barring folic acid if we do absolutely need it too).

Please let me know if this makes sense and how you are doing now. Thank you! Dmitry

[emcilia]

Thank you Dmitry. I still have pure bulk niacin powder and will use it today with Swanson iron capsule. Will I need to take folic acid too?

[AJ West]

Hi Emanuele!

Glad you have the correct iron citrate! You will still need to take folic acid as below:

The easiest dose by preserving whole number of capsules of the three best, would be multiplying this by 4 as so:

1.125 g niacin per 1.125 mg folic acid per 1 Swanson Iron Citrate (Ferric Citrate aka Iron(III) Citrate aka Fe3+ Citrate) capsule (which is 25 mg ferric ion each capsule as shown on the back) * 4

1.125 g niacin * 4 = 4.5 g niacin

1.125 mg folic acid * 4 = 4.5 mg folic acid

1 Swanson Iron Citrate capsule * 4 = 4 Swanson Iron Citrate capsule (or 4 * 25 mg ferric iron = 100 mg ferric iron)

=

4.5 g niacin

4.5 mg folic acid

4 Swanson Iron Citrate capsules

=

9 niacin (preferably PureBulk 500mg each) capsules

4.5 folic acid (since PureBulk doesn’t make capsules, preferably Dr. Clark 1 mg capsules (I COMPLETELY FORGOT about those, which are also BOVINE CAPSULE, to get exactly half, you can weigh out the contents of one, take out half the mass, then put that back into the capsule or into another bovine gel one) but also we have Pure Encapsulations which are 800mcg each, then would be Solgar which are 800 mcg each (can also get 400mcg caps of each of these last two companies)

4 Swanson Iron Citrate capsules

So basically, most preferably:

9 niacin (PureBulk 500mg each) capsules

+

4.5 folic acid (Dr. Clark’s 1mg each) capsules

+

4 Swanson Iron Citrate capsules

…

This dose, obviously, would be for those more experienced and not very first timers (unless in more serious situation)…