Dr.Kats
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Dr.Kats and
suzanneicalvert62gmail-com are now connected 3 weeks ago -
Dr.Kats posted an update 3 weeks ago
3 weeks ago (edited)
CONCEPTUAL FRAMEWORK OF INFINALIFE
The below was disseminated to a member in their specific case, note, but I believe it applies to all while in general in terms of biology. Hence, I am relaying it below in hopes of getting more needed attention to https://HOM3OSTASIS.com/InfinaLife :
Why IV / “pre-made” NAD feels so strange
NAD⁺ inside the body is not really a nutrient; it’s an…
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The small free-Trp fraction that travels with the NA is the first time your cells are seeing a clean pulse of free tryptophan at the same moment that NAD⁺ demand is being covered by NA. That combination is what tells the system, “stop sacrificing tryptophan into that oxidative sink, and start letting the tryptophan from your food go back to…
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Outstanding explanation! Thank you for sharing this.
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Really helpful teaching, thank you. I had no idea that tryptophan contributed to protein synthesis and tissue repair. Also, that the ascorbic acid was actually interfering. InfinaLife is the elegant solution, awesome.
Dmitry, do I need a special code for placing the first order so I can receive the double amount?
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Dr.Kats posted an update 3 weeks ago
1. What this paper actually found
Hutchings et al. describe the norit eluate factor as:
• Acidic in nature
• Containing an amino group
• Destroyed by strong acid
• Stable to alkali
• Found in vitamin-free casein but destroyed if casein is completely hydrolyzed
• Molecular weight ≈ 500
• Phosphorus not required for its biological…
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Dr.Kats posted an update 3 weeks ago
JUST PUBLISHED
Niacin, an active form of vitamin B3, exerts antiviral function by recruiting β-arrestin through GPR109A to activate the phosphorylation of ERK and STAT1 axis
https://journals.asm.org/doi/full/10.1128/jvi.01519-25 -
Dr.Kats posted an update 3 weeks ago
Sugar cravings indicate low serotonin (consuming carbohydrates can temporarily boost serotonin levels) and ergo, low tryptophan and coupled to that, deficient nicotinic acid.
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Can you comment on the relationship between low serotonin and low tryptophan? I’ve never been able to tolerate it and am a massive sugar addict, and on SSRI’s most of my life; wondering if it’s related. Thanks!
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Just saw the article below but it’s way too much for me to synthesize. 😋
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Most people think: “Tryptophan → serotonin → melatonin, so I’ll just take more tryptophan.”
That’s chemically true, but physiologically incomplete — because tryptophan metabolism is hierarchy-based, not democratic.
The body assigns tryptophan to three competing pathways:
1. NAD⁺ (niacin) synthesis via kynurenine — primary survival…
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Wow, thank you! It’s interesting because I’ve tried oral and nasal NAD supplementation with no results, but when I tried IV I literally couldn’t tolerate (metabolize?) it and had to stop the drip. I’m just back on the NA, using up the last of the NA/AA combo and then will try the new combo.
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Ok, thank you! Ordering.
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Dr.Kats posted an update 4 weeks ago
Sorry for the delay in getting orders out. I wanted to confirm the ratio more before. All orders will be going out this weekend!
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Dr.Kats posted an update 4 weeks ago
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Dr.Kats posted an update 4 weeks ago
4 weeks ago (edited)
L-Tryptophan supplementation regulating immunity
”Trp supplementation in piglets markedly enhances alpha diversity and althers beta diversity of the intestinal microbiome.
Trp administration decreases the abundance of opportunistic pathogens (e.g., Clostridium sensu stricto) and increases the abundance of Trp-metabolizing bacteria (e.g., Lactobacillus).
Our recent experiments also verify that…
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Sounds like GPR109A eh?
“Confronting LPS-induced TJ injury, dietary Trp supplementation inhibits the NF-κB-myosin light-chain kinase signaling pathway and activates the extracellular regulated protein kinase (ERK) 1/2-mitogen-activated protein pathway, which restores the intestinal barrier integrity.”
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Dr.Kats posted an update 4 weeks ago
4 weeks ago (edited)
Realize the key of Tryptophan coming in exogenously as the FREE-FORM Tryptophan
“Because of the low fractional extraction of free tryptophan in the brain, the synthesis of 5-HT will be dependent only upon the free pool of tryptophan.”
https://pmc.ncbi.nlm.nih.gov/articles/PMC1133271/
pmc.ncbi.nlm.nih.gov
Models of tryptophan catabolism and binding to serum albumin are presented to explain the observed effect of displacement of tryptophan from albumin on the concentrations of free and bound tryptophan and on the rate of 5-hydroxytryptamine (5-HT) ...
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And not just that:
“Research is uncovering tryptophan’s role beyond mood regulation—it’s becoming vital for muscle recovery. Studies show enhanced protein synthesis linked to tryptophan intake. As recovery nutrition evolves, expect this amino acid to take center stage by 2025.”
https://x.com/signal_synapse/status/1983982735606620572?s=46
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“the results demonstrate that for there to be sustained increases in free plasma tryptophan after displacement of bound tryptophan, there must be rapid dissociation of tryptophan from albumin (compared to the transit time of tryptophan through the major catabolic organ, the liver) and there must be a significant fractional extraction of the free…
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Now imagine, this limited-as-shit as it is incoming supply of free-form L-tryptophan, simultaneously having to excessively deplete/oxidize down to NAD+ in lieu of nicotinic acid supplementation. What then, do you have left for serotonin-melatonin and for protein synthesis?!?!?
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“Since the output flux is now greater than the input flux, the concentration of free tryptophan will decrease until steady-state is obtained. It is clear that, in A, B and C, displacement of bound tryptophan cannot produce sustained increases in free tryptophan concentration (and hence brain 5-HT synthesis); this is because the rates of…
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“It can be calculated that complete removal of the bound tryptophan will have only very small direct effects on tryptophan concentrations within the brain and thus on 5-HT synthesis.”
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Dr.Kats posted an update 5 weeks ago
JUST PUBLISHED
“milk tryptophan content and availability decrease among WLWH, which may indicate perturbations in milk tryptophan catabolism”
Altered milk tryptophan and tryptophan metabolites in women living with HIV
https://www.nature.com/articles/s41467-025-64566-w
nature.com
Altered milk tryptophan and tryptophan metabolites in women living with HIV - Nature Communications
Children born to women living with HIV suffer increased morbidity and, in low-income settings, have two to three times the mortality of infants born to women without HIV. Here, we profile the milk metabolome of 326 women living with and … Continue reading
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