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athena333 posted an update
Reminder! Before you go out to an appointment, be sure to print out Dr Kats’ cards or stuff like that. Yesterday I was telling my mother’s eye doctor what we’re taking here from Hom3ostasis and the eye doctor was interested in finding out more about how that works out for my mother.
I was wishing I had been smart enough to have printed this info out. I underscored that we were getting this straight from Merck b/c Dr Kats was getting COAs and I couldn’t remember what the other authenticating document was like USP or something?Anyway. Just wanted to offer the suggestion in case anyone else needed that reminder.
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Yes, the stuff is all from them, but for “research use” … and USP = United States Pharmacopeia, which is like an overriding nonprofit authority that makes strict guidelines for any chemicals that intend to eventually be used in humans, which was the only option for folic acid. These products are the same, but they come with their USP-guidelines-met Certificate of Analysis, and given that more “official”, standardized rubric applied, have to undergo more thorough testing even if shown to be 100% pure. All Rx (prescription) pharmaceutical drugs, which many may have originated from one or a combo of these three nutrients, are required by law and regulated by FDA to undergo these strict tests and to be proved in such documents as COAs (which can be called upon by the pharmacist if needed). Otherwise, the supplement industry is just legal drug dealing, filled with companies that en masse purchase recycled mystery toxic waste powders on the bulk Chinese market (coming with no tests to assess the identity, purity, or quality control) to then flip to consumers at lower costs (given the low costs of no tests and the bulk Chinese market). As a business owner in this field, why would you do differently if there are no consequences or regulations for poisoning people to make more money, to even succeed in the supplement industry? I would love to work with eye doctors too.
There exists an overload of literature, including research (beaucoup on GPR109A aka HCAR2, specifically) and experimental in animal models, all the way up to multiple double-blind randomized placebo-controlled trials proving the safety and efficacy of these nutrients, namely formally nicotinic acid but the others too, to provide ample environments causally contributing to, governing ocular health too…
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High Dose Oral Niacin as a treatment for Retinal Vein Occlusions
https://iovs.arvojournals.org/article.aspx?articleid=2358905Effect of oral niacin on central retinal vein occlusion
https://link.springer.com/article/10.1007/s00417-017-3606-0-
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THE ROLE OF GPR109 IN REGULATION OF
RETINAL ANGIOGENESIS AND BLOOD-RETINAL
BARRIER AS A POTENTIAL THERAPEUTIC
TARGET IN DIABETIC RETINOPATHY
https://augusta.openrepository.com/bitstream/handle/10675.2/623721/Abdelrahman_gru_1907E_10195.pdf?sequence=1&isAllowed=y -
GPR109A as an Anti-Inflammatory Receptor in Retinal Pigment Epithelial Cells and Its Relevance to Diabetic Retinopathy
https://iovs.arvojournals.org/article.aspx?articleid=2188684 -
Hydroxycarboxylic acid receptor 2 (HCAR2/GPR109A) expression and signaling promotes the maintenance of an immunoinhibitory retinal environment
https://www.biorxiv.org/content/10.1101/2021.03.15.435493v2 -
“Results: Vitamin B₆ and vitamin B₁₂ intake was not associated with EG/SEG risk in pooled analyses (P = .52 and P = .99 for linear trend, respectively). However, a suggestive trend of a reduced risk was observed with higher intake of folate: compared with the lowest quintile of cumulatively averaged updated total folate intake, the multivariable relative risk for EG/SEG for the highest quintile (≥654 μg/d) was 0.75 (95% CI, 0.54-1.04; P = .02 for linear trend). These results were not materially altered after adjustment for vitamin B₆ and vitamin B₁₂ intake. An association was observed for supplemental folate intake but not for dietary folate only (P = .03 and P = .64 for linear trend, respectively). Greater frequency of multivitamin use showed a modest suggestive inverse association (current multivitamin use of ≥6 times per week vs nonuse multivariable relative risk, 0.84; 95% CI, 0.64-1.11; P = .06 for linear trend).”
https://pubmed.ncbi.nlm.nih.gov/24699833/ -
“In the 2005-2008 NHANES population, higher levels of niacin intake were associated with decreased odds of glaucoma overall and in women.”
https://journals.lww.com/glaucomajournal/abstract/2023/06000/associations_between_niacin_intake_and_glaucoma_in.1.aspx -
Restored retinal physiology after administration of niacin with citicoline in a mouse model of hypertensive glaucoma
https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1230941/full
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Association of dietary intake of B vitamins with glaucoma
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“Our study demonstrates significant inverse associations between higher intakes of vitamin E, vitamin B9, and niacin and a reduced risk of developing cataracts, especially in high-intake groups.”
Vitamin E, Vitamin B9, & Niacin on Cataract Incidence
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1406147/abstract -
Association Between High Blood Folate Levels and Glaucoma in a Representative Korean Population
https://iovs.arvojournals.org/article.aspx?articleid=2793251
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Anemic Retinopathy: Case Reports and Disease Features
https://retinatoday.com/articles/2016-may-june/anemic-retinopathy-case-reports-and-disease-features
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So much interesting information! Thank you so much, Dr. Kats!
I’ve been working on reading these a little at a time.
I appreciate this information SO much!
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