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83377 posted an update
The molecular basis underpinning the potency and specificity of MAIT cell antigens.
Awad, W., Ler, G.J.M., Xu, W. et al. Nat Immunol 21, 400–411 (2020).
Published 02 March 2020
DOI: 10.1038/s41590-020-0616-6
doi.org
Mucosal-associated invariant T (MAIT) cells recognize vitamin B metabolites presented by the molecule MR1. Rossjohn and colleagues generate multiple altered metabolite ligands and determine their structures in the context of MR1 and the TCR to develop a generalized framework for … Continue reading