-
nickandcarol posted an update
Hi Folks, We are new here. We haven’t started the protocol yet as we are still waiting for the delivery from Pure Bulk. We work in the health world, having run our own organic, natural foods and remedies retail shop for over 30 years. We both have a passion for research and like to ‘practice what we preach’ and have moved our health in a generally positive direction over the years. We did try niacin some years ago after reading Dr Andrew Saul’s book, but did not keep it up for long unfortunately.
What has led us here is problems Nick has been having with damage to his eyes from glaucoma. He was aware he had cataracts developing and was resistant to going to the hospital. When he eventually did go, it was discovered that he had very high eye pressures. He had no idea as there was no discomfort. The lenses were both replaced and various treatments/surgeries tried to reduce the pressures but nothing really helped until Paul tube surgery that seems to have stabilised things at a good level. Over this time the optic nerve in one eye became damaged leading to restricted vision and the cells in the cornea were damaged in the other eye leading to cloudy vision.
We came across research from Moorfields Eye hospital in the UK where they were trying NMN and NR to help to repair optic nerve damage. So Nick decided to try this. Anyway, we have since found your work, Dmitry and have stopped these and are now waiting for the niacin/glutamine to arrive.
We have a few questions….
Have you come across any evidence of niacin helping eye problems such as these?
Also, you suggest stopping all supplements and meds when doing this protocol. Nick is still using a minor steroid eye drop and also a pressure eye drop. He has been dealing with a huge amount of anxiety around the prospect of loosing his sight and so is concerned about stopping these drops as we cannot know if his eye pressures are going up without the hospital’s testing equipment. Also, for how long would you suggest supplements need to be stopped? He doesn’t take loads, but the things he is finding helpful are Remag, C60, PureSleep (also from Pure Bulk) and something called StemEnhance Ultra. Do you have any advice here, maybe?
1 Comment-
Thank you first of all.
To get to the point though, please do not touch that NR or NMN or any salvage precursor other than flush niacin (powered with equimolar glutamine). Thank goodness you found me, because I can assure you this was one huge reason your eyes were deteriorating more. The work I do is not my work, but rather, simply report of the truth (a lot of it from my research, yes, but all corroborated in those who did not perform as deep of research I did to arrive to niacin). We know in humans (have known for quite some time, just they don’t tell you of course) that higher order animals above inbred lab rodents they use for NMN, NR testing, don’t have just one pathway where all the precursors, including niacin, flow to NAD+ … in humans, most especially, flush niacin makes the NAD+… literally nothing else. Everything else is “adaptive” mechanism if niacin (and glutamine) are too deficient. This is why there will never ever be a published RCT in humans (or beyond inbred lab rodents they use) showing any type of benefit for these salvage NAD+ precursors that are fueled into disease as a result of the lack of flush niacin to NAD+, powered by enough glutamine (at least something in terms of those two, you know.. there is not even 1/100th enough daily in adult diet to live healthily let alone prevent a single pesticide exposure upon crossing the threshold where the body just can’t protect without severe injury, with disease sequelae if survived or death):
See here and here – https://www.hom3ostasis.com/2022/11/homo-sapien-vs-hom3ostasien/
Supplementation of nicotinic acid and its derivatives up-regulates cellular NAD+ level rather than nicotinamide derivatives in cultured normal human epidermal keratinocytes
https://www.researchsquare.com/article/rs-2481861/v1There is an abundance of research + clinical literature on niacin’s ocular-related beneficial effects. Powered by glutamine, you are going to be in for a treat. I will link some below. With eye drops, I would not go overboard. Let me tell you something… I am not rich, so I have been saving my (needed sensitive-eye as I have horrrrible vision and astigmatism) night/day-wear contact lenses that should be replaced every 1 month for the past maybe 6 months, as I am on my last pair (for the past 6+ months lol). Upon realizing glutamine with niacin a month or so ago, they still feel as if new. Before, I would wake up like the old days with shittier lenses and have to take them out and feel the burn for a good 0.5 day. Now not anymore.
Hence, you should see there is no need for these drops going forward.
Below follows the aforementioned links (and some more goodies) so you can have the truth at least on paper before you enjoy it more in person…
“Participants with a niacin intake greater than 21mg per day (quartiles three and four) had a significantly lower risk of glaucoma compared with those with niacin intake of less than 15.33mg per day (quartile one),”
the researchers noted in their paper.Dec 29, 2022
https://www.reviewofoptometry.com/news/article/vitamin-b3-may-lower-risk-of-glaucoma“There was a significant decrease in the crude odds of self-reported glaucoma in the third (OR 0.57, 95% Cl 0.43–0.76; p < 0.001) and fourth (OR 0.57, 95% Cl 0.37–0.90; p = 0.018) quartiles of daily niacin consumption, which equated to 21.01 to 28.22 mg/day and greater than 28.22 mg/day, respectively. A similar trend was found using fundus imaging of subjects with niacin intake in the third (OR 0.42, 95% Cl 0.25–0.72; p = 0.002) and fourth (OR 0.36, 95% Cl 0.20–0.67; p = 0.002) quartiles. After adjusting for covariates, the odds of glaucoma based on fundus imaging remained significantly lower for niacin intake in the third (OR 0.49, 95% Cl 0.28–0.87; p = 0.016) and fourth (OR 0.48, 95% Cl 0.26–0.89; p = 0.022) quartile levels. Using ISGEO criteria, there was no significant association between glaucoma and daily niacin consumption. Conclusions: Greater niacin intake may be associated with a lower chance of developing glaucoma.”
Association between Daily Niacin Intake and Glaucoma: National Health and Nutrition Examination Survey
https://www.mdpi.com/2072-6643/13/12/4263“Glaucoma is the most common cause of age-related blindness in the United States. There is currently no cure, and once vision is lost, the condition is irreversible. Williams et al. now report that vitamin B3 (also known as niacin) prevents eye degeneration in glaucoma-prone mice (see the Perspective by Crowston and Trounce). Supplementing the diets of young mice with vitamin B3 averted early signs of glaucoma. Vitamin B3 also halted further glaucoma development in aged mice that already showed signs of the disease. Thus, healthy intake of vitamin B3 may protect eyesight.”
Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice
https://www.science.org/doi/10.1126/science.aal0092
…Little do people know, as they don’t care to review the actual literature, that per se, akin to every other cell in the body, as proved in these high-profile journal-published papers the miserable (collecting Internet-dust) the only growing lack of dietary flush niacin (and with that glutamine), these days, is also literally the cause of all clinical conditions/disease:
For example, just from double blinded randomized placebo-controlled human trial and/or full-population cohort data…
Liver:
“None of the patients taking IR [immediate release aka ‘flush’] niacin developed hepatoxic effects, while 12 (52%) of the 23 patients taking SR niacin did. —The SR [sustained release, altered] form of niacin is hepatotoxic and should be restricted from use. … The IR niacin is preferred for the management of hypercholesterolemia”
A Comparison of the Efficacy and Toxic Effects of Sustained- vs Immediate-Release Niacin in Hypercholesterolemic Patients
https://jamanetwork.com/journals/jama/fullarticle/366299“In our study, high niacin intake during lifestyle intervention was associated with a larger reduction of liver fat content without affecting insulin sensitivity”
“Among 58 subjects with nonalcoholic fatty liver disease (NAFLD) at baseline, NAFLD resolved in 23 subjects during the lifestyle intervention. For one standard deviation increase in niacin intake, the odds ratio for resolution of NAFLD was 1.77 (95% CI, 1.00–3.43). High niacin intake may have a favorable effect on the reduction of liver fat during lifestyle intervention”
Niacin Intake Predicts the Decrease of Liver Fat Content During a Lifestyle Interventionhttps://www.nature.com/articles/s41598-018-38002-7“pharmacologic (high-dose) niacin offers a potential treatment for liver cirrhosis, the clinical manifestation of liver fibrosis. This study offers a clue that niacin may reverse fibrosis resulting from other causes of cirrhosis including viral, alcohol, chemicals, etc.”
“this study shows for the first time that NIACIN:
* reverses preexisting collagen deposition in liver fibrosis associated w/ NASH
* prevents & reverses collagen deposition induced by oxidative stress in non-fibrotic stellate cells
* should be repurposed as an effective drug for clinical treatment of patients with NASH-fibrosis or liver cirrhosis
* has known efficacy for reversing steatohepatitis and steatosis (which can also result in liver cirrhosis)
* in patients with fibrotic NASH or liver cirrhosis is suggested as a cost-effective therapy for a major unmet need in clinical medicine.”
Niacin regresses collagen content in human hepatic stellate cells from liver transplant donors with fibrotic non-alcoholic steatohepatitis (NASH)
https://
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9274597/Kidneys:
The efficacy and safety of niacin on hyperphosphatemia in ESRD patients undergoing hemodialysis: randomized controlled trial
https://jnephropharmacology.com/Article/npj-10569Effect of niacin on phosphorus, calcium, parathormone and vitamin D levels in hemodialysis patients; a double-blinded randomized clinical trial
https://ejim.springeropen.com/articles/10.1186/s43162-021-00080-xCancer (soooo many more):
Association between niacin and mortality among patients with cancer in the NHANES retrospective cohort
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-022-10265-4Heart/CVD/Metabolic Control:
“This meta-analysis involved 2,110 patients with T2DM from 8 RCTs across a wide range of patients’ characteristics. The results of this study suggested that niacin supplementation significantly reduced TC, TG, & LDL, and increased the level of HDL.”
Effectiveness of niacin supplementation for patients with type 2 diabetes
A meta-analysis of randomized controlled trials
https://journals.lww.com/md-journal/fulltext/2020/07170/effectiveness_of_niacin_supplementation_for.94.aspx
“Niacin use significantly increased HDL-C by 29% and 29% and decreased triglycerides by 23% and 28% and LDL-C by 8% and 9%, respectively, in participants with and without diabetes.”
Effect of Niacin on Lipid and Lipoprotein Levels and Glycemic Control in Patients With Diabetes and Peripheral Arterial Disease
The ADMIT Study: A Randomized Trial
https://jamanetwork.com/journals/jama/fullarticle/193064
“niacin therapy had typical effects on routine clinical lipids (HDL-C + 16%, q < 0.01; LDL-C − 20%, q < 0.01; and triglyceride − 15%, q = 0.1)”
Effect of niacin monotherapy on high density lipoprotein composition and function
https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01350-3
“niacin retains an FDA-approved indication as monotherapy for treating dyslipidemia, a main risk factor for cardiovascular events and myocardial infarction”
“Stratified meta-analysis showed an association of niacin monotherapy with reduction of some cardiovascular events among patients WITHOUT statins (acute coronary syndrome: relative risk, 0.68; 95% CI, 0.58-0.96; stroke: 0.69; 95% CI, 0.59-0.94; revascularization: 0.51; 95% CI, 0.37-0.72). These results were mainly derived from 2 trials conducted in the 1970s and 1980s”
Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes
A Systematic Review and Meta-analysis
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2730481
“Our study concludes that lipid-modifying dosages of niacin can be safely used in patients with diabetes and that niacin should be used for patients with diabetes to sufficiently correct hypertriglyceridemia or low HDL-C levels.”
Effect of niacin on lipid and lipoprotein levels and glycemic control in patients with diabetes and peripheral arterial disease: the ADMIT study: A randomized trial. Arterial Disease Multiple Intervention Trial.
https://read.qxmd.com/read/10979113/effect-of-niacin-on-lipid-and-lipoprotein-levels-and-glycemic-control-in-patients-with-diabetes-and-peripheral-arterial-disease-the-admit-study-a-randomized-trial-arterial-disease-multiple-intervention-trial
“concluded from many clinical trials using statins, lowering LDL-C alone is no longer regarded to be sufficient to treat CVD
comprehensive lipid management, in which raising HDL is an important target, a new standard. Niacin is UNSURPASSED in raising HDL”
Niacin Increases HDL by Reducing Hepatic Expression and Plasma Levels of Cholesteryl Ester Transfer Protein
https://ahajournals.org/doi/10.1161/atvbaha.108.171363
“link is supported in humans by epidemiological data demonstrating a correlation between intake of NAD+ precursor niacin (nicotinic acid) & vascular health, & LDL. In fact, niacin is an FDA-approved therapy for reducing LDL, ApoB, TG, and for raising HDL”
NAD+ in COVID-19 and viral infections
https://cell.com/trends/immunology/fulltext/S1471-4906(22)00025-4
^ High triglyceride to HDL-cholesterol ratio as a biochemical marker of severe outcomes in COVID-19 patients
https://clinicalnutritionespen.com/article/S2405-4577(21)00162-5/fulltext
Low HDL and high triglycerides predict COVID-19 severity
https://nature.com/articles/s41598-021-86747-5
Triglyceride/High-Density Lipoprotein Cholesterol Ratio is Associated with the Mortality of COVID-19
https://dovepress.com/triglyceridehigh-density-lipoprotein-cholesterol-ratio-is-associated-w-peer-reviewed-fulltext-article-IJGM
High-density lipoproteins may play a crucial role in COVID-19
https://virologyj.biomedcentral.com/articles/10.1186/s12985-022-01865-4
HDL cholesterol levels and susceptibility to COVID-19
https://thelancet.com/journals/ebiom/article/PIIS2352-3964(22)00347-4/fulltext
Causal Inference for Genetically Determined Levels of High-Density Lipoprotein Cholesterol and Risk of Infectious Disease
https://ahajournals.org/doi/10.1161/ATVBAHA.119.313381
The Triglyceride to High-density Lipoprotein Cholesterol Ratio, an Estimate of Insulin Resistance, is Associated with Incident Coronary Heart Disease. The Atherosclerosis Risk in Communities (ARIC) Study
https://ahajournals.org/doi/10.1161/circ.133.suppl_1.mp37^ High triglyceride to HDL-cholesterol ratio as a biochemical marker of severe outcomes in COVID-19 patients
https://clinicalnutritionespen.com/article/S2405-4577(21)00162-5/fulltext
Low HDL and high triglycerides predict COVID-19 severity
https://nature.com/articles/s41598-021-86747-5
Triglyceride/High-Density Lipoprotein Cholesterol Ratio is Associated with the Mortality of COVID-19
https://dovepress.com/triglyceridehigh-density-lipoprotein-cholesterol-ratio-is-associated-w-peer-reviewed-fulltext-article-IJGM
High-density lipoproteins may play a crucial role in COVID-19
https://virologyj.biomedcentral.com/articles/10.1186/s12985-022-01865-4
HDL cholesterol levels and susceptibility to COVID-19
https://thelancet.com/journals/ebiom/article/PIIS2352-3964(22)00347-4/fulltext
Causal Inference for Genetically Determined Levels of High-Density Lipoprotein Cholesterol and Risk of Infectious Disease
https://ahajournals.org/doi/10.1161/ATVBAHA.119.313381
The Triglyceride to High-density Lipoprotein Cholesterol Ratio, an Estimate of Insulin Resistance, is Associated with Incident Coronary Heart Disease. The Atherosclerosis Risk in Communities (ARIC) Study
https://ahajournals.org/doi/10.1161/circ.133.suppl_1.mp37“Participants in an open label study at Kaiser Permanente in San Francisco received an average of 3000mg a day. After a mean duration of one year, 81% of patients had experienced reductions in intra-abdominal fat as measured by a single slice abdominal CT scan (the method agreed to provide an objective measure of changes in body fat). The average reduction in those who experienced improvement was 27%, and the degree of fat loss was significantly associated with the degree of increase in HDL cholesterol (niacin is given to people with elevated cholesterol to increase levels of good HDL cholesterol), and a reduced Total Cholesterol/HDL cholesterol ratio.”
Niacin reduces abdominal fat: pilot study
https://aidsmap.com/news/feb-2002/niacin-reduces-abdominal-fat-pilot-study
“Here, we demonstrated that oral supplementation of niacin resulted in a significant reduction in body weight and fat mass without affecting food intake in highfat diet-fed”
“Additionally, we demonstrated that niacin treatment stimulated thermogenesis in brown adipose tissue by induction of thermogenic genes via GPR109A”
“GPR109A deficient animals display obesity”
“niacin exhibited a markedly decrease in HOMA-IR values, suggesting the beneficial role of niacin in insulin sensitivity”
Niacin Fine-Tunes Energy Homeostasis Through Canonical GPR109A Signaling
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3237699
“The findings suggest that niacin exerts beneficial effect on adiposity, glucose tolerance and insulin sensitivity, and plasma lipids, and that it specifically modulates the level of serum adiponectin under obese condition.”
Niacin improves adiponectin secretion, glucose tolerance and insulin sensitivity in diet-induced obese
https://sciencedirect.com/science/article/pii/S2314808X15000615
“Our research demonstrated that intake of niacin prevents the prevalence rate of cardiovascular disease by inhibiting low HDL-cholesterol and hyperglycemia”
“In conclusion, all the results from this research show the highest prevalence rate of cardiovascular diseases from physiological factors: hypertension, waist size, low HDL-cholesterol, and the nutrient that was related to the abnormal rate of physiological factors was niacin.”
Relationship of Niacin with Cardiovascular Disease
http://kjcls.org/journal/view.html?doi=10.15324/kjcls.2019.51.4.484
“The findings reveal that macrophage GPR109a deficiency accelerates the development of T1D [Type 1 Diabetes]. Activation of GPR109a on macrophage by nicotinic acid may provide a new strategy for preventing or treating T1D.”
GPR109a Regulates Phenotypic and Functional Alterations in Macrophages and the Progression of Type 1 Diabetes
https://onlinelibrary.wiley.com/doi/10.1002/mnfr.202200300Cognitive/Functional Decline into Neurodegeneration/Dementia:
“Dementia is CAUSED by severe niacin insufficiency”
Conclusion:
“niacin protects against AD and age related cognitive decline”
Dietary niacin and the risk of incident Alzheimer’s disease and of cognitive decline
https://jnnp.bmj.com/content/75/8/1093“niacin improves AD mice’s cognitive ability through multiple mechanisms: reducing Aβ formation, improving mitochondrial metabolism, regulating autophagy, and reducing inflammation, which has been reported. Our research also found that niacin can improve AD cognitive ability through circadian rhythm, ubiquitin-mediated proteolysis, and long-term potentiation.”
“Niacin supplementation is a safe and simple choice for AD prevention and treatment. Niacin can enhance cognitive capacity in AD through a variety of
mechanisms”
https://medicine.iu.edu/news/2022/03/niacin-alzheimers-researchNicotinic acid supplementation contributes to the amelioration of Alzheimer’s disease in mouse models
https://atm.amegroups.com/article/view/101529/html“Grip strength, although not significant, showed a trend of increasing strength bilaterally in the niacin group, but not with placebo over six months of treatment. Grip strength is well-known to correlate with longevity, so this could be a predictor of increased life expectancy by taking niacin [27]. Almost all reported secondary measures demonstrated a trend towards improvement over one year.
Most notably, serotonin levels, fatigue, and grip strength stood out in our study. Serotonin levels were significantly lowered in the placebo-treated group but not in the niacin-treated group after the first six months. The FSS scores were markedly better in the niacin-treated group but not the placebo group from six to twelve months. Both of these findings may explain the reporting of an uplift in mood reported by PD subjects who received niacin for one year.”
“5. Conclusions
The findings presented here show that treatment with low-dose daily niacin supplementation compared to placebo resulted in significantly improved motor function outcomes. We have already demonstrated that niacin acts by polarizing the activated microglial cells in the brain and reducing GPR109A expression in white blood cells, thus reducing neuroinflammation. Our findings support the use of low-dose niacin supplementation in PD as an adjunct therapy that can reduce neuroinflammation and improve motor functions in PD patients.”
Low-Dose Niacin Supplementation Improves Motor Function in US Veterans with Parkinson’s Disease: A Single-Center, Randomized, Placebo-Controlled Trial
https://www.mdpi.com/2227-9059/9/12/1881…
Every disease and aging itself:
https://www.hom3ostasis.com/2022/11/homo-sapien-vs-hom3ostasien/
-