Dr.Kats
Forum Replies Created
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Aww @jess – thank you so much for the wonderful update and praise! It means a lot. And truly, THIS is EXACTLY what I work for. I am so happy to hear that the family is all doing well! It’s going to be a very very very long ride now in life, so we’re just getting started! I can’t wait till we are all in our hundreds (looking in our 20s 30s), and I can write back – told ya so!
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The next one will be smoother… way smoother. And @seankettle – did you see your questions answered in the script above?
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Do people see this?
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Got it!
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Treatment of deafness
https://www.periodicos.capes.gov.br/index.php/acervo/buscador.html?task=detalhes&id=W2033095037
Full text here: https://sci-hub.ru/10.1288/00005537-194008000-00006
periodicos.capes.gov.br
The LaryngoscopeVolume 50, Issue 8 p. 773-783 Article Treatment of deafness† Dr. Louis K. Guggenheim, Dr. Louis K. Guggenheim West Los AngelesSearch for more papers by this author Dr. Louis K. Guggenheim, Dr. Louis K. Guggenheim West Los AngelesSearch for … Continue reading
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Effect of ascorbic acid on the numerical hair cell loss in noise exposed guinea pigs
https://www.sciencedirect.com/science/article/abs/pii/0378595588900263 [full text PDF attached]-
And another one:
Relationship Between Diet and Tinnitus: Korea National Health and Nutrition Examination Survey
https://e-ceo.org/m/journal/view.php?id=10.21053/ceo.2017.01221
e-ceo.org
:: Clinical and Experimental Otorhinolaryngology
:: Clinical and Experimental Otorhinolaryngology
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Gonna hunt down the full soon:
Nicotinic acid treatment of tinnitus; a clinical; audiological examination
https://pubmed.ncbi.nlm.nih.gov/13227997/
pubmed.ncbi.nlm.nih.gov
Nicotinic acid treatment of tinnitus; a clinical; audiological examination - PubMed
Nicotinic acid treatment of tinnitus; a clinical; audiological examination
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lolz
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So which dose ratio are you doing exactly of the GPR109A capsules to Swanson iron citrate capsules (assuming you have this Swanson iron citrate: https://www.swansonvitamins.com/p/swanson-premium-iron-citrate-25-mg-60-veg-caps)? It looks to be best at 5 GPR109A Capsules (which is 1,250 mg or 1.25 g flush niacin worth) with every 1 Swanson iron citrate capsule (25 mg “iron” on the back). I know we had it way too high at first (at even flipped, 4.5 Swanson iron citrate capsules per 1 GPR109A capsules), but we had no reference point to go off. We now know it’s way closer to and may be right around 5 GPR109A capsules (1.25 g niacin) per 1 Swanson iron citrate capsule (25 mg “iron”). Let me know which ratio you were doing…
Also, along with the Swanson Iron Citrate capsules, do you happen to have solo, separate products of flush niacin by Pure Bulk (whether in capsules or powder) and folic acid by Pure Bulk (or someone else, but make sure it is only folic acid and not methylfolate), separately? It is worth trying niacin + iron citrate in ratio of 1.25 g niacin + 25 mg “iron” (i.e., 1 Swanson iron citrate capsule) OR niacin + folic acid + iron citrate in ratio of 1.25 g niacin + 1.525 m(illi)g(rams) folic acid + 25 mg “iron” (i.e., 1 Swanson iron citrate capsule) — that is, without the acetylglutamine. Per what we are learning about iron citrate, especially some of these brand new papers, it looks like the dysregulation of glutamine/amino acids metabolism (and the lack of that little bit of folic acid) may be subordinate endogenously to namely the iron (citrate) and niacin deficiency, in that restoring simply iron citrate with niacin (ideally at ideal stoichiometric ratio together, whatever that exactly is, but it looks to be no less than an amount of 1.25 g niacin (which note is 2.5 Pure Bulk flush niacin 500-mg each capsules) per each 25 mg “iron” (i.e., 1 Swanson iron citrate capsule). I believe supplementing ANY kind of amino acids (including even acetylglutamine and especially the heat-labile free l-glutamine as we saw before) may be worthless to supplement, especially during a pellagra (which looks to be namely a niacin + iron (citrate) deficiency, potentially folic acid too, but I believe we can circumvent it), as again, it is seeming to be uncovered that all amino acids’ metabolisms, including glutamine/glutamate’s (the most important/regulating of all amino acids) are regulated by iron status, modulated in fine-tune by niacin-GPR109A. Given acetylglutamine is coming at the highest amount of all components, I feel for the most sensitive people coming in, that it may slow down or simply conflict with the uptake and efficient processing/metabolism of the others. If we can restore all these aminos’ metabolism with less components, then it is what it is. That’s the route. With that, the updated product I would make is like a GPR109A+, which will consist of the finalized ratio of niacin-to-iron citrate (and barring folic acid if we do absolutely need it too).
Please let me know if this makes sense and how you are doing now. Thank you! Dmitry
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Hello Andrew!
This is certainly discouraging to hear, albeit the worst of it should be over now. With individual powders, not having all three nutrients (and not just one dose but as you see for weeks continued) consistent can lead to unpredictable exacerbations like this. This is what makes the https://GPR109A.com already worth it, given niacin, folic acid, and N-acetyl-L-glutamine are precisely fused with no hassle but also now given that we will not have to try to exhaust dosage so much as we were without this key IRON CITRATE I mention in the most recent post on our HOM3OSTASIS feed here.
I do believe with ANY history of nagging gout, especially with an out-the-blue flare-up like this, mandates precisely-tuned application and most especially, consistently whilst trying to minimize variance (and given the relative mass of folic acid being so minute, we are asking for something to go wrong as the body remodulates (and this is in fact one major reason Pharma makes drugs so the patient does not have to prepare it himself). GPR109A product linked above (or here directly: https://purebulk.com/products/GPR109A?sca_ref=1004090.8JspdBHd04) should massively circumvent this caveat. Furthermore, adding the Swanson iron citrate per the newest post as spot-therapy alongside, which should simultaneously really ease having to chase doses of GPR109A with the proper iron citrate coming now. Meanwhile, combining 1-2 capwules of the proper-linked iron citrate to recoup it as per my newest post), the GPR109A individual dose sizes, even in the worst-case scenarios, I feel, will remain no more than 4 g niacin anchors (with the other two in proper ratio), with response coming smooth, rapid as it has been the case with all three per GPR109A for those less iron deficient.
The dysregulation of iron is a common feature then that leaves iron in cells no longer staying in flux through and so accumulating and oxidizing. This iron overload isolated to certain cells or regions of the body has nothing to do with what actually delivering (the proper) iron (with its identified factors alongside) as we are here will be doing. In fact, herein, the purpose of the iron citrate spot-boost/therapy is to restore the deficiency systematically through the body that led to per se, iron overload in individual cells/organs (literally left more to die with the limited iron going to cells more favorable). We literally have EVERYTHING but the actual iron substrate … which in fact I had (iron) along with folic and niacin.. just not N-acetyl-L-glutamine as now but selenium. Please let me know if this makes sense so far…. (as well as my above newest post on this).
Thank you. Please do not worry.
https://kidneystones.uchicago.edu/2014/11/22/citrate-to-prevent-stones/
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So this dopamine depletion over life goes side-by-side with flush niacin’s lack (to fuel so many things including literally all of dopamine per the 0.96 significant correlation coefficient in the below recent paper that showed how in-line flush niacin deficiency is in chronic fatigue), and then not addressing this developing flush niacin/NAD+ deficiency with needed supplementation over the life course thereafter (and of course before recognizing this) will lead to the niacin receptor becoming growingly exposed to inflammation/oxidative stress into literally getting damaged/disabled/burned out, in turn limiting flush niacin to restore NAD+ solo. <- Because as this happens and the demand for NAD+ (proton motive force to keep energy current into, through, and out cells to make ATP going) grows further, glutamine accordingly grows increasingly deficient in then being readily available (and in growing need more) to process more needed NAD+ as these sequelae unfold more unaddressed.
“Niacin and DA levels of the patient group were significantly lower than those of control group (p=0.003 and p=0.02, respectively). A very strong positive correlation was found between niacin and DA levels (r=0.96 p<0.001).”
Evaluation of clinical relationship of serum niacin and dopamine levels in patients with fibromyalgia syndrome
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305637/^ Since flush niacin’s established anti-inflammatory causal therapeutic powers — to restore energy metabolism in cells and ultimately health in the host — to happen most efficiently are contingent directly upon the degree of the expression of its GPR109A receptor of each cell corresponds in-line to (and not short of) indeed how much inflammation, free radicals, cellular debris, gunk, pathogens, particles, toxins, etc. there are in the cell, signaling to niacin to bind to it to come into the cell and fully address + provide proton motive force/H+ (from the bigger molecules, NAD+ and NAADP, exclusively niacin, catalyzed by available glutamine, makes without rate limit) to keep the cells going thereafter, not addressing the growing niacin/NAD+/NAADP+ deficiency over the life course, especially upon worsening health status &/or over aging, will side-by-side lead to available glutamine deficiency concordantly, rendering the need for available glutamine that diet can no longer fulfill to be supplemented with flush niacin. The below collection of papers can explain why you may have in fact been a bit overweight (respective to what would have been a more ideal weight), how you despite engaging in college sports-level activity were still not getting the most out of the exercise or yourself out into the exercise performance, as well as (along with this dopamine deficiency in-line with niacin’s) the depressive symptomatology manifesting over the meanwhile.
“The present study reported that higher BMI was causally associated with lower glutamine levels. Both obesity and downregulation of glutamine were causally linked to depression.”
Causal Association Between Obesity, Circulating Glutamine Levels, and Depression: A Mendelian Randomization Study
https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgac707/6889636?login=false
Niacin fine-tunes energy homeostasis through canonical GPR109A signaling
https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fj.201801951R
Nicotinic Acid Improves Endurance Performance of Mice Subjected to Treadmill Exercise
https://www.mdpi.com/680136The Effect of Substrate Utilization, Manipulated by Nicotinic Acid, on Excess Postexercise Oxygen Consumption
https://sci-hub.ru/10.1055/s-2007-972600Niacin Beneficially Alters the Secretion of Intestinal HDL in a Rat Model of Insulin Resistance by Opposing Effects on PPAR Alpha and TNF Alpha
https://www.ahajournals.org/doi/10.1161/atvb.34.suppl_1.629…
With all that, have you gotten to higher doses of flush niacin + N-acetyl L-glutamine? As someone more fit, trained, and physically/energetically active over life up to this point and especially now trying to get back into the groove (& what you will see, already are seeing but don’t realize it yet fully, will be further gains), you are going to need higher doses, even if you were ideally healthy, but especially from the get-go for therapeutic purposes from a non-niacin-supplemented life coming in and simultaneously to take further advantage of the (especially cumulative) additive (potentially even synergistic) benefits of what engagement in leisure-time physical activity can further provide on-top. Already you are experiencing the preliminary reduction of now how many decades of extra mass/energy (of let’s just imagine it’s just diet we are talking about here) accruing through the ins and outs through your body and liver — paramountly the accumulating stores of fat deposits in the liver (dumping in there from what is extracted from diet for the liver to make ATP) that remain not able to make ATP to any ideal pace to not accumulate over age no matter what we do if it’s not supplementing niacin, thereby limiting VLDL-TG secretion out when too much overload of this fat develops in the liver, and effectively comprehensively through circulation, minimizing the need to continue to have fat (even carbs support fat when fat becomes too overloaded in liver) have to accumulate to support ATP requirements as we age.
Exclusively nicotinic acid, (flush) niacin through its innate GPR109A receptor does what exercise does mechanically spot-on first of all, in that by through its endothermic processing turning to bigger molecules, NAD+ & NAADP+, at-will if provided with adequately available glutamine catalyzing this biosynthesis in cells, we readily start burning and limiting the propagation of excess fat through our body by providing the potential energy simply via niacin continuing to the physically bigger molecules, NAD+ and for proper phagocytosis/clearance of particles, even bigger, NAADP+, and without limitation of these conversions’ rate (if niacin, acetylated glutamine, clean water, & decent-enough diet are sufficiently supplied) BUT without having to invest any work/potential energy and thus ATP. If relying on strictly exercise engagement as the only actually other feasible strategy to expend (especially cumulatively via consistent engagement over decades) clinically relevant levels of excess energy from accumulating instead of relying on only the flush niacin-deficient diet w/o exercise activity participation (i.e., even worse / the general population aka the “control”), those more persistently physically active during leisure-time will still imminently, once each of them reach a certain number, X later age, not physically be able to prevent progression to a threshold level of accumulation of fat in/through the liver and overload through the body. Simply, without niacin-GPR109A going via sufficient supplementation of flush niacin + N-acetyl L-glutamine, trying to sustain biological function in such a fashion via “stores” of energy sooner or later results in the liver fattening, inflammation + ROS/RNS propagating, into further clinical conditions, disability, frailty, and disease over the life epoch (and concordantly or eventually, if without obesity or any extra weight, into the erosion of our bone marrow, with it, even DNA & RNA, being burned off to provide ATP, as the glutamine availability runs out more & more over life), we will try to recoup/store with diet later). We cannot rely on solely exercise (on top of well-balanced, decent diet), given the fact that not only is the magnitude of the energy expenditure from even the most intense possible exercise meager compared to the potential energy a single niacin-GPR109A dose provides and so we get dramatically less release of energy through exercise, but even further, we have to actually perform increasing amount of work with exercise to expend this much relatively less release of energy? With mechanical/kinetic body movement to burn the fat, that is (more intense, if trained to) physical activity, we try to put the FFAs into literally enough acute movement to release the potential energy stored in their previously in-tact/idle bonds. Meanwhile, swallowing and bowel movement is literally minimal work, and for perhaps thousands times of output energy expended per intense exercise bout. And the cherry on top, with sufficient niacin/acetyglutamine/GPR109A going, we do not have to recoup (any amount of any) ATP that was initially provided through the investment for it by the mechanical work of effort-intense exercise.
What this means is that a life characterized by initiating and preserving adequate supplementation of niacin/NAG, i.e., dynamic maintenance of modulated/regulated GPR109A, could be perceived as one that can remain (or if after the fact of not starting life supplementing, first recoup to then assume the ability to then remain) in a state towards persisting in thermodynamic equilibrium of energy transferred in, out, and through (all the cells as parts and a simultaneously, a sum of them, of) the organism system (that is, you, attached to the ecological outside environment universe of limitless energy source).
What I think is going on in your individual case, is that you are dosing too low (and to a degree, not often enough) still, particularly at this point of trying to shift to ideal health into gains from exercise on top. To this point, with lower dosing, you have been observing literally the burning-off and clearance of the excess mass/energy aforementioned (i.e., predominately the accumulated stores of fat incoming), given your weight is dropping and simultaneously you are likely also not having to eat as much meanwhile not to forget, having to support further this more intense activity participation. However, at the same time, you are not leaving much extra niacin-GPR109A to harness their further abilities to have you quite energized and consistently, into finally getting the most out of exercise. Being 190 lbs necessitates a bit higher dosing versus average 150 lb adult at this point (and maintained for a bit more and a bit higher thereafter relatively versus average adult for health maintenance) to support just basal metabolic rate and so definitely even more to support exercise gains whilst expecting to remain energized through the days then even more so further.
Lastly, I do think it is worth considering this: https://t.me/c/1804009892/6041
Please let me know if this makes sense…
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Hello Jon. Are you taking the proper N-acetyl L-glutamine per the finalized https://HOM3OSTASIS.com/Protocol, with flush niacin, and NOT the preceding less-stable, slightly improper free l-glutamine (with flush niacin)?
Also, could you please give me a bit more detail on the dosing and your dimensions/activity levels prior to these recent revelations?
Thank you!
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How is it going with the N-acetyl L-glutamine in replacement for the free l-glutamine, of course with equimolar flush niacin? From the observations I am getting back so far from various suffering from all sorts of cancers, ever single one of them is doing stellar upon just a few doses even (and not even that high) of flush niacin + N-acetyl L-glutamine … this is what I hope to see across the board forward for all …
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So you are trying to chase the niacin to do more, however, at this stage of not addressing the niacin deficiency until a certain point, niacin became underpowered to get into cells more and do more therapy as you want until the proper l-glutamine (which originally we figured the free form l-glutamine would readily suffice, but it turns out it’s the acetylated form we want, N-acetyl-L-glutamine as per outlined on https://HOM3OSTASIS.com/Protocol ) is delivered alongside. This glutamine gets depleted in the body and even tried to form endogenously in emergency mechanisms then to try to provide energy source in lieu of niacin (and to try to make niacin to NAD+ more) as niacin remains deficient and unaddressed for too long, and then recouping niacin via supplementation of it as monotherapy (i.e., without proper glutamine) can only get so deep as you’re experiencing. As soon as the glutamine (provided in acetylated form) starts coming with niacin in equimolar amount (so delivered in ratio of whatever niacin mass is in grams, multiply by 1.53 to get n-acetyl-l-glutamine dose to come with it, e.g. 1 g flush niacin + 1.53 g n-acetyl-l-glutamine), you will experience niacin at last getting deeper readily to address these deeply stubborn issues too. This is because niacin’s GPR109A receptor that signals how much work niacin needs to do and so how much niacin can bind to it and get into each cell, becomes more downregulated and unable to signal the according work as much that niacin needs to do more, as the inflammation and oxidative stress in a way keep it concealed/inactive to be reupregulated for niacin and induce actual damage that more glutamine now is needed, that the body does not have anymore to give, to start rebuilding and resignalling and restoring for niacin to get into the cells now fully.
I would make sure to get only PureBulk flush niacin and n-acetyl l-glutamine (as linked in https://HOM3OSTASIS.com/Protocol), powder (with precision scale linked) and/or powder (with scale) + bovine gelatin capsules… if they are sold out, which they are of n-acetyl-l-glutamine, get the Bulk Supplements’ linked here (preferably powder as I do not know if the 100-count capsules are bovine gelatin): https://www.bulksupplements.com/products/n-acetyl-l-glutamine
Also, do you have a Telegram? We have a private group/chat for exclusively HOM3OSTASIS.com members like you that provides quicker, more dynamic communication access with everyone in compliment to this News Feed and the Groups/Forums here…
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Certainly … before I divulge further, have you acquired/evaluated N-acetyl-L-Glutamine yet?
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This is the easiest thing flush niacin does like clockwork, no questions asked, proved in countless trials… do you mean low HDL- cholesterol?
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Yes, all of the iron mishap is typical of the over-aging anemia-like features that develop as flush niacin (and with this, folates, which are made by flush niacin’s NAD+ and in fact l-glutamine catalyzing this final conversion of niacin to NAD+) grows undersupplied (from diet) over the life course (and especially exasperated over COVID days). As mentioned, given niacin + glutamine is needed to replenish these folates and end this stupid methylation pathway (which only went haywire like this to try to compensate for the lack of niacin, in this way really using up the any available glutamine/glutamate stores we had to support then the salvage mechanisms to continue to make NAD in lieu of niacin), you started running out your folate stores with the glutamine/glutamate stores to make up for the over use of methylation intermediates like the methylfolates and cobalamin as well as methionine that become higher in demand and get used up overloading trying to make salvage NAD+ and niacin intermediates then when that overloaded to make NAD+ in lieu of niacin. The acetylated glutamine (N-acetyl-L-glutamine) is going to overcome all of these issues, especially as it will allow for all the glutamine to come and meet up with flush niacin down the stomach into the colon through the intestines. This in turn will restore the iron, hemoglobin, and erythrocytes transfer of iron + nutrients homeostatically.
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Naturally… yes… yet another pellagric manifestation they attribute to mysteries for our furry ones to get jabbed (and die over life) too…
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You are referring to garbage papers with simply conceptual theorization (and misconception on their part) with authors who do not understand the glutamine metabolism as trying to provide glutamine to the cancer cells so they do NOT cancer (more then too), but still NOT enough glutamine… you do NOT kill/toxify/oxidize cancer cells to kill them / cure the cancer and you … no .. that will only kill you … the cancer cells, themselves, are still our actual cells, just making ATP the only way they can favorably now (by way of lack of niacin, glutamine to provide enough energy flux) via glycolysis and so making lactate more = the actual tumor … it is still the SAME CELL … just need actual exogenously delivered glutamine with niacin to remodulate and turn it back to the mitochondria and not have the lactate buildup = cure of cancer …
These same authors who made up these stupid attempts to say glutamine being the only fuel source for cancer cells to not die/fail and you die but still have the opportunity to be readily reverted back/cured, is fueling cancer growth are reckless and just flat-out wrong. You realize this when you finally do experimentation, including in humans rather than thoughts in the head. The idiots who falsely recklessly claim these lies about glutamine, of course, then also do this as so-called rationale to starve glutamine further (and killing the cells and you further) by inhibiting then even endogenous metabolism of it with their garbage, expensive Nazi nerve agent inhibitors (to KILL the cell… thus you… slowly, painfully)…
“Our data support the hypothesis that glutamine is a likely alternative energy source during niacin deficiency”
“Since the levels of NAD in niacin deficient cells are greatly reduced, it is likely that NAD-depleted cells are incapable to sustain their energy requirements solely by glycolysis. Therefore, niacin deficient cells would require an additional carbon source. One such source available from the cell culture media is glutamine. We hypothesized that if glutamine is a crucial carbon source for NAD-depleted cells, these cells would be far more sensitive than control cells if it was removed from the media. Completely eliminating glutamine from the media lead to cell death both in control and depleted cells”
Niacin restriction upregulates NADPH oxidase and reactive oxygen species (ROS) in human keratinocytes.
https://europepmc.org/article/med/17997992…
“One concern about the administration of Gln to cancer patients is that it would be employed by rapidly proliferating cells, including malignant cells,51 with the potential enhancement of tumour growth. However, some experimental data appear to indicate that dietary supplements do not increase tumour growth,52 rather, it diminishes growth53,54 by enhancing NK cell activity through the support of host Gln stores and glutathione (GSH) production. Presently, it remains to be clarified as to whether Gln might inhibit tumour metastasis”
“we demonstrated for the first time in this study that Gln [glutamine] inhibited PAF-associated tumour metastasis, in which MAPKs perform a critical role, via the deactivation of ERK, JNK, and p38 MAPKs.”
Glutamine inhibits platelet-activating factor-mediated pulmonary tumour metastasis
https://sci-hub.ru/10.1016/j.ejca.2011.07.013…
“We further demonstrated that dietary glutamine supplementation partially increased glutamine levels and restored potent antitumor responses”
Glutamine is essential for overcoming the immunosuppressive microenvironment in malignant salivary gland tumors
https://biorxiv.org/content/10.1101/2022.04.29.490103v1…
“Taken together, our results provide a previously unidentified mechanism by which glutamine supplementation inhibits melanoma tumour growth and suggests a previously unrealized therapeutic avenue using glutamine supplementation in melanoma to cooperate with current therapies and potentially combat resistance mechanisms. Furthermore, our results provide important evidence that glutamine supplementation, rather than the nutrient-limiting approaches, is a simple dietary intervention that has the potential to block melanoma tumour growth and potentiate the effects of anti-melanoma treatments by suppressing epigenetically activated oncogenic pathways.”
Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth
https://nature.com/articles/s41467-020-17181-w…
“The overall incidence of postoperative complications was 14.9 and 36.8% in the glutamine and control groups, respectively, indicating that glutamine significantly reduced the incidence of postoperative complications [p < 0.001; risk ratio (RR) 0.41 [95% CI 0.30–0.54]]. Compared with the control group, the glutamine group had a significantly lower postoperative infection complications rate (10.5 vs. 28.9%; p < 0.001; RR 0.36 [95% CI 0.26–0.52]).”
“Moreover, glutamine supplementation alleviated the decrease in albumin (p < 0.001), total protein (p < 0.001), and prealbumin levels (p < 0.001).”
Postoperative parenteral glutamine supplementation improves the short-term outcomes in patients undergoing colorectal cancer surgery: A propensity score matching study
Tang, Gang et al in Frontiers in Nutrition (2023.03)
https://frontiersin.org/articles/10.3389/fnut.2023.1040893/full
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So at 80 lbs, the conversion from average 148 lb adult would be represented by taking (80/148) * the typical doses divulged in protocol for average adult, i.e., 2.5 g flush niacin + 3 g glutamine (or half that), coming out to what would be starting around anywhere from 0.676 g flush niacin + 0.803 g glutamine to 1.353 g flush niacin + 1.605 g glutamine. You can then go up in this ratio to up to 5x, so up to 6.763 g flush niacin + 8.027 g glutamine. I think you will see up to the 4 g range should be sufficient early, but likely not needed that high but worth evaluating if dog is responding well from earlier dosing. Thereafter the therapy first few week or two, you can gravitate towards standard between 1.353 g flush niacin + 1.605 g glutamine and maybe up to double that should be solid. I think once a day is fine, especially as you identify whatever the needed dosing is (my 20 lb cats are at a bit under 1 g levels usually but have gotten higher early to evaluate)…
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Yes. And nothing else is.
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Ah, I meant that for the niacin and glutamine above, and yes the thyroid medicine is basically wannabe niacin, so not needed. See here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1824202/
The flushing is totally normal – sign of the inflammation and gunk clearing… he will feel better and better with higher dosing.. likewise, the flushing will calm down and even be non-existent soon as he gets more and more out
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Keep it going – his body is accommodating and getting gunk out! I would go higher and higher here earlier
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Yes, this is typical not necessarily just “detox” but niacin.glutamine trying to repair too – you are accumulating more niacin.glutamine to get things going but still not enough juice. For instance, look at how much niacin (ignore niacinamide) Hoffer reported some patients with arthritis had to take – essentially all higher than the levels you’re at now … you should have started at the levels you’re at now and your arthritis would probably be fully gone by now lol … I would keep going up with dose – even 5/6 and beyond levels, and I think you will see how real this is … also, are you using distilled water?
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THE DISTILLED, CLEAN AS POSSIBLE, COLDISH WATER (H20) IS GOING TO BE HUUUUUGE FOR SMOOTHNESS AND EFFICIENCY, I DO BELIEVE … and on this note … to update:
the molar to mass ratio of the three together, flush niacin : glutamine : water would lead to one as so:
For every 1 gram flush niacin, 1.187 grams glutamine, and 5 oz of water
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The former is correct. And moreover, vitamin A is not really a vitamin so no need for it. If you think you need A, that’s a niacin and tryptophan deficiency
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We don’t need methyl donors… we need efficient NAD+ … all those listed in the above Table are endogenous metabolites
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I will touch on these notable points DA makes too, but on this note, remember that “toxicity” itself was originally defined (by Krehl) as what increases requirements for NAD+ essentially… this underlying theme of NAD+ regeneration is core here, as I will touch on in greater detail during the Q&A!
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Yes, this is a solid strategy given the prolific safety … this IS safety without really any upper limit / “too much” … but at the same time, I will try to address how we can more informatively track this, which many want that reassurance
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Excellent Question, Anna! I will delineate these key points during the Q&A as well!
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Yes, I will address this during tonight’s Q&A too. But for prelude: ha, AI–unless programmed better–will invariably off the jump misnomer niacinamide as “niacin”. Niacinamide–unlike nicotinic acid = actual niacin–will lead to more demand of folate, given the extra methylation needed to de-amidate niacinamide to become actual niacin aka nicotinic acid to then turn to NAD+. Without enough C and/or tryptophan meanwhile with sufficient nicotinic acid going, depending on niacinamide to turn to niacin then NAD+ more will demand more methylation in this way in turn. However, niacin will not have this problem, and all folate (which is not supposed to be exogenously supplemented in the first place, but endogenously cycled via sufficient amounts of these three identified nutrients in CNT) will be restored as DA showed above with the triad of the three in proper ratio ideally as we have.
When was your blood test taken which showed folate still low in terms of when you started added tryptophan to C and (actual) niacin in proper ratio?
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I ran into the below paper across my re-review of my literature review on this topic:
MÉNIÈRE’S SYMPTOM COMPLEX
Its Relation to Chemistry; an Etiologic Study
GRANT SELFRIDGE, M.D.
https://jamanetwork.com/journals/jamaotolaryngology/article-abstract/585241
^ Full text attached as PDF to this message below…
I have copy-pasted the most important parts below and below that, provided links for the citations:
“Guggenheim [11] referring briefly to Ménière’s syndrome, cited the finding of Somyngi that in allergic states there is depletion of potassium salts in the cells and increase of these salts in the body fluid and that the depletion is corrected through administration of potassium and insulin. He also mentioned a case in which petechial hemorrhages and presence of blood in urine and stool suggested the possibility that permeability of the stria vascularis, increased through deficiency of ascorbic acid, was a cause of Ménière’s disease. He stated further that the most important agent in the prevention of neural degeneration in Ménière’s disease is the vitamin complex, i. e., thiamine and nicotinic acid.
Atkinson [12] contributed a thorough and satisfactory review of the subject. He concluded that allergy and histamine sensitivity accounted for 20 per cent of his cases and that the remaining 80 per cent, cases in which the patient was nonsensitive, were related to lack of nicotinic acid. In 69 of 108 cases data were available for analysis. Relief of vertigo was reported in 32 cases. He considered the disease the result of a constriction of the vascular supply. In a letter dated Feb. 14, 1944, he wrote:
‘I have just completed another paper on my results in 110 patients treated with nicotinic acid. In this series the tinnitus was removed entirely in 13 cases (12 per cent) and improved in 42 (40 per cent). Thus, in half the cases one can achieve an appreciable improvement in this symptom.’
[…]
Adams [14] related deficiency of ascorbic acid to asthenia and Ménière’s disease, in both of which there are apt to be autonomie imbalance and vasomotor disturbances. He observed several cases in which ascorbic acid was absent from the urine, probably because of lack of this vitamin in the diet, and in which the condition was improved or entirely relieved by an increased intake of fruit and food containing ascorbic acid. He referred to O’Dell’s suggestion that lack of this vitamin was a frequent cause of Ménière’s syndrome. In several cases Adams used some of the factors of the B complex [i.e., nicotinic acid] in addition to ascorbic acid.
[…]
Ménière’s disease is a function of the aging process. Talbott and associates [15] in a tabulation of 33 cases, showed that the patients were all 50 years old or older. In my studies, all the patients with eighth nerve deafness who were 40 years of age and over showed definite loss of high tones, severe in most of them. In all the cases the urine showed nicotinic acid definitely low; in half the cases it showed porphyrin increased. When the eyes were checked for dark adaptation by Dr. Evelyn Blanchard with her ‘reginometer,’ the results were out of line in nearly all cases. Many of the patients were 60 years of age and over. It should not be forgotten that the aging process frequently begins in early childhood and not infrequently before birth. Stieglitz [16] made the comment that premature development of the changes of senescence in one or more organs might well be caused by particular dietary deficiencies of the parents and that the geriatric, anatomic and functional changes of the thyroid, pituitary and adrenal glands may be influenced by heredity, by the nutrition of the parents at the time of conception and by the nutrition of the mother before and after birth. The far reaching effect of nicotinic acid deficiency, for instance, has been depicted graphically by Frostig and Spies [17] and others.”
[…]
The experimental dog, Benny, of Morgan and Simms [18] (fig. 1) shows an aging process induced by dietary measures that may have a definite analogy to that of human life. At the age of 6 weeks this dog was restricted to a diet deficient in nicotinic acid and some other unknown. He showed considerable irregularity of gait, especially in the hindlegs, suggesting some disturbance of the vestibular apparatus. The aging process was evidenced by changes of posture, increasing grayness of hair, increasing ptosis of belly muscles and finally inability to stand erect. The dog died at the age of only 3 years; the average life span of a cocker spaniel varies from 8 to 12 years. Inasmuch as this dog’s diet was normal except for the lack of nicotinic acid and some other unknown, it seems obvious that the aging appearance and the pathologic changes are related to the missing factors. The autopsy report showed that the principal organ involved was the adrenal cortex.
[…]
I have noticed that in patients with this type of ear who also complained of stuffy nose and postnasal drip, mucoid in character, with no pus present, improvement followed administration of riboflavin (30 mg. daily) or a vitamin B complex preparation [i.e., nicotinic acid] with ascorbic acid added.”
Citations:
11. https://sci-hub.ru/10.1288/00005537-194008000-00006
12. https://sci-hub.ru/10.1001/archotol.1943.00670030047004
14. https://sci-hub.ru/10.1288/00005537-194008000-00006
15. https://sci-hub.ru/https://doi.org/10.1017/S0022215100004539
16. https://sci-hub.ru/https://doi.org/10.1037/h0052720
17. https://sci-hub.ru/10.1001/archotol.1941.00660040135014
18. https://sci-hub.ru/https://doi.org/10.1093/jn/19.3.233
Good stuff!
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Krehl observed that adding ascorbic acid to a high-protein diet [i.e., one highest in tryptophan] caused a rapid weight gain in female control animals.
The Relation of Diet Composition and Vitamin C to Vitamin A Deficiency: One Figure
Yale Nutrition Laboratory, Department of Physiological Chemistry,
Yale University School of Medicine, New Haven, Connecticut
Mayer Jean*, Krehl W.A.
* Rockefeller Fellow
https://sci-hub.ru/https://doi.org/10.1093/jn/35.5.523
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“Six proposed COVID‐19 therapeutics were identified as possessing ototoxic side effects including chloroquine and hydroxychloroquine, azithromycin, lopinavir‐ritonavir, interferon, ribavirin, and ivermectin.”
“Many previously or currently used COVID‐19 therapeutics have known ototoxicity including antimalarials, macrolide antibiotics, immunomodulatory agents, and antiviral therapies. Ototoxicity refers to drugs that cause functional impairment or cellular damage to tissues of the inner ear including both the cochlear and vestibular system, often manifesting as hearing loss, tinnitus or disequilibrium.”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8014300/
ncbi.nlm.nih.gov
The purpose of this review is to summarize evidence‐based data regarding the ototoxic effects of potential COVID‐19 therapeutics to treat patients suffering from SARS‐CoV‐2. Medications under investigation as novel therapeutics to treat COVID‐19 ...
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Please forget about NAG … and I am not sure what “Niacin” you are referring to, if it is coming from PureBunk like the NAG was… it is the wisest decision you have ever made in your life you will see getting the real niacin and vitamin C that I am packing now… It is finally real niacin and niacin’s wife (what we needed the whole time with it, which was NOT NAG, but NAG helped us get closer, just like everything else we had tried out to arrive at last to vitamin C).
Yes, there were several articles posted over COVID showing a strong association of HCQ use and tinnitus incidence occurring. Certainly the toxicity can lead to this, especially where a high demand of both nicotinic and ascorbic acids are dynamically necessary to maintain the hearing anatomy and electric conduct. Not to worry though, as nicotinic and ascorbic acids that you will get are established mechanistically to overcome this. Niacin solo was not equipped enough for many who had it the worst coming in, however, over time I did observe how it solo quelled the tinnitus eventually. What has been missing especially in this hearing arena to most efficiently restore the anatomy, current, and function is alongside with niacin, the vitamin C that was (especially by HCQ) at a very fast rate depleted and more and more as the initial niacin requirement was not met sufficiently forward (which can’t be met without C at a certain point).
So all in all, I am extremely confident that you are going to get rid of your tinnitus and most likely restore back your entire hearing and the actual tissue/connections there back to even better than before. After I am done today with boxes, I can pick up where I left off here and trace down some relevant research + clinical papers on this very topic for you too. Thanks!
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If you are gonna come in here, still not having even tried a drop of the only actual medicine, flush niacin + N-acetylglutamine, and already asking for “other products,” then it is clear to me that you have nothing here to bring for anyone but trying to discourage them from healing. Is that the case?
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LET ME MAKE THIS CLEAR: A 1.0 CORRELATION MEANS THEY ARE LITERALLY DIRECTLY GOVERNED BY THE SAME EXACT MECHANISM 1-TO-1 … 0.96 CORRELATION BETWEEN FLUSH NIACIN AND DOPAMINE LEVELS …
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WHAT OTHER PRODUCTS?!?! DO YOU THINK I HAVE NOT CONSIDERED “OTHER PRODUCTS” OR SOMETHING?!?!?
“Niacin and DA levels of the patient group were significantly lower than those of control group (p=0.003 and p=0.02, respectively). A very strong positive correlation was found between niacin and DA levels (r=0.96 p<0.001).”
Evaluation of clinical relationship of serum niacin and dopamine levels in patients with fibromyalgia syndrome
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How are you feeling so far after a few days, Jon?
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Yes, exactly – this would be the most efficient method if you have the PureBulk bovine gelatin capsules, which are literally the powders in the simple capsule that allows it to be released with no microcrystalls like the veggie cellulose capsules… I have this noted on the left side of https://HOM3OSTASIS.com/Protocol that we can just take the contents out the bovine gel capsules and dump into glass of water… so yes this is totally cool and even preferred method with capsules… also, you are able to access Telegram on your cell phone no problem… please review these directions:
If you are a currently active HOM3OSTASIS.com member but are not yet in the aforementioned private Telegram chat/group, then if not already please download Telegram (available here free: https://telegram.org/apps – you can use a computer &/or mobile), register/sign up/open your account (you will see – it really is the best communication app, imho), DM (direct message) me on the Telegram app (via this direct URL link: https://t.me/HOM3OSTASIS_com or within the app &/or once in the app, clicking the bottom ‘Chats’ (icon of two, blue-colored message boxes/bubbles) and at the top ‘Search’ or ‘Search chats’ typing in my user name, HOM3OSTASIS_com to search, come up, and click to message) with your message confirming the email address attached to your currently active HOM3OSTASIS.com membership account, and once I confirm on my end, I will either directly invite you into the private group/chat or if your default privacy/security settings do not permit that, reply back to your DM with an invitation link for you to simply click to gain access into the private group/chat.
It will be key to replace the free l-glutamine with the acetylated proper version, N-acetyl L-glutamine per https://HOM3OSTASIS.com/Protocol to get the most out of glutamine (how it’s supposed to come) and with that, niacin too…
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Excellent! So at least for some, niacin and with the acetylated form, glutamine, are now packing a mighty punch
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Very nice! These issues with free l-glutamine were from it not being there with niacin given free l-glutamine’s heat lability and probably also because n-acetyl-l-glutamine IS the meant glutamine to supplement too… curious – did you find any specific dosing level of flush niacin + l-acetyl-l-glutamine that has been the call-it “sweet spot” for you yet?
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Ah yes, okay, I saw in Telegram…
So check out this paper:
Nicotinic acid treatment of tinnitus; a clinical; audiological examination
https://sci-hub.ru/10.3109/00016485409123998^ As you will see, the results with nicotinic acid, alone, and across various kind of subtypes of tinnitus, is variable – some good (notice it was not immediate response usually), some okay, a few meh. Hence, we know there is something missing with flush niacin (aka nicotinic acid)…
…
“For tinnitus, it has been hypothesised that the excessive release of glutamate between the inner hair cell and the terminal fibres of the auditory nerve at the synaptic cleft, as a result of noise exposure, for example, may generate tinnitus. Excess glutamate may lead to increased expression of glutamate receptors, making cells increasingly sensitive to the excitatory neurotransmitter, resulting ultimately in excitotoxicity.”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458046/
….
“as a brain function improving agent, NAG [N-acetyl-L-glutamine] decomposes the excitatory Glu [glutamic acid / glutamate] and the inhibitory GABA to sustain homeostatic mechanisms of brain.“
“NAG [N-acetyl-L-glutamine] increases the content of GABA in the brain to counteract excessive Glu [glutamic acid / glutamate] and maintains the balance of brain function.”
https://www.frontiersin.org/articles/10.3389/fphar.2020.00508/full
…
^ Unmistakably tinnitus looks to be a result of inflammation overwhelming through these inner ear areas over aging and/or exposure to noise (which we become more sensitive to over aging), along with exposure to toxic agents such as very toxic prescription drugs, whether you take them or not, from the environment (with more actually purposefully taking, we get more shed into the environment and thus us), and/or purposefully taken as “medications” as so:
“Six proposed COVID‐19 therapeutics were identified as possessing ototoxic side effects including chloroquine and hydroxychloroquine, azithromycin, lopinavir‐ritonavir, interferon, ribavirin, and ivermectin.”
“Many previously or currently used COVID‐19 therapeutics have known ototoxicity including antimalarials, macrolide antibiotics, immunomodulatory agents, and antiviral therapies. Ototoxicity refers to drugs that cause functional impairment or cellular damage to tissues of the inner ear including both the cochlear and vestibular system, often manifesting as hearing loss, tinnitus or disequilibrium.”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8014300/
“According to reports, IVM [ivermectin] can be used as an agonist of glutamate to enhance the opening frequency of glutamate-gated chloride (GluCl). A low concentration of ivermectin can enhance the action of neurotransmitters, and a high concentration of ivermectin can enhance cell membrane permeability to chloride ions”
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011188
…
With that, I expect the flush niacin + n-acetyl-l-glutamine to intervene here quite causally as well, as always, and for successful, curative results. However, give it a bit of time to manifest fully as well as some good rest. Try not to focus on if you are going to have a tinnitus-like feeling incoming per se, when it often occurs for many, before bed each night forward. Within a week or two, you may just have realized that you do not have it anymore after you realize you stopped thinking about having it. This is usually how it goes away for people who have had niacin pretty much cure it within a week or two, albeit these people were not as glutamine-deprived, particularly in these cells, explaining their success with niacin solo. Nonetheless, please do not worry. Let it come. We got the proper glutamine coming now.
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Further… attached is a very nice book written by this Dr. Parsons going over flush niacin’s causal application to cholesterol modification:
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This is easy work for flush niacin (especially with equimolar N-acetyl-L-glutamine to boot) per https://HOM3OSTASIS.com/Protocol :
“This meta-analysis involved 2,110 patients with T2DM from 8 RCTs across a wide range of patients’ characteristics. The results of this study suggested that niacin supplementation significantly reduced TC, TG, & LDL, and increased the level of HDL.”
Effectiveness of niacin supplementation for patients with type 2 diabetes
A meta-analysis of randomized controlled trials
“Niacin use significantly increased HDL-C by 29% and 29% and decreased triglycerides by 23% and 28% and LDL-C by 8% and 9%, respectively, in participants with and without diabetes.”
Effect of Niacin on Lipid and Lipoprotein Levels and Glycemic Control in Patients With Diabetes and Peripheral Arterial Disease
The ADMIT Study: A Randomized Trial
https://jamanetwork.com/journals/jama/fullarticle/193064
“niacin therapy had typical effects on routine clinical lipids (HDL-C + 16%, q < 0.01; LDL-C − 20%, q < 0.01; and triglyceride − 15%, q = 0.1)”
Effect of niacin monotherapy on high density lipoprotein composition and function
https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01350-3
“niacin retains an FDA-approved indication as monotherapy for treating dyslipidemia, a main risk factor for cardiovascular events and myocardial infarction”
“Stratified meta-analysis showed an association of niacin monotherapy with reduction of some cardiovascular events among patients WITHOUT statins (acute coronary syndrome: relative risk, 0.68; 95% CI, 0.58-0.96; stroke: 0.69; 95% CI, 0.59-0.94; revascularization: 0.51; 95% CI, 0.37-0.72). These results were mainly derived from 2 trials conducted in the 1970s and 1980s”
Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes
A Systematic Review and Meta-analysis
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2730481
“Our study concludes that lipid-modifying dosages of niacin can be safely used in patients with diabetes and that niacin should be used for patients with diabetes to sufficiently correct hypertriglyceridemia or low HDL-C levels.”
Effect of niacin on lipid and lipoprotein levels and glycemic control in patients with diabetes and peripheral arterial disease: the ADMIT study: A randomized trial. Arterial Disease Multiple Intervention Trial.
“concluded from many clinical trials using statins, lowering LDL-C alone is no longer regarded to be sufficient to treat CVD
comprehensive lipid management, in which raising HDL is an important target, a new standard. Niacin is UNSURPASSED in raising HDL”
Niacin Increases HDL by Reducing Hepatic Expression and Plasma Levels of Cholesteryl Ester Transfer Protein
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They are not understanding the full mechanisms… and the clearance of it out… or the interplay of glutamine … I have a discussion on this here, if you would like to check it out:
https://hom3ostasis.com/groups/gout-uric-acid/forum/discussion/gout-try-try-again/
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Ah, I forgot to link the paper (which is now linked below):
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1831040/
Before this last smaller dose, when was the last time you took a relatively larger sized (e.g., beyond 1.5 g) dose?
The levels you are at are going to be good but still you will see you should respond to higher ones (but let them process) earlier better…
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@sandyriv – good to hear that the second one was much relatively calmer and hopefully calm in general. Now imagine that first dose being 5x call-it “worse” had you done the traditional 500-600 mg dose… I do believe these first reactions even if 5x higher, i.e. at more needed levels to get the show on the road going, have a lot to do with the novelty of this experience of finally getting remedy… there are deep psychological roots involved that are being activated into then playing a role on every little thing we perceive that we hope is alright, escalating into a trippy, often unpleasant experience, whatever the dose is, but especially if too unpowered coming in… the worst is over with always with the first dose, and ideally we do not want to start therapy and then stop because it was too bewildering… akin to getting cut open for a surgery without anesthetic putting you out for those first cuts… please keep me updated … your body looks to be accommodating quite well now … do not be afraid to do higher dose … or lower … but the 2.5/3 seems like a minimum around to keep at for the next week … play around with pulsing even too … and before and after meals … whenever is best for you … do not be surprised if you get some needed deep, beauty sleep back too even out the blue .. or if suddenly your energy levels are on blast if you were chronically fatigued before … the body wants to smoothly rectify to homeostasis of course, but we have to understand we have a lot to rectify and the process is not a walk in the park … but the worst is over … enjoy … you should be feeling like yourself again and beyond within a week ….
